Evidence map›Paper›PMID 40006552›Full record

ReviewPharmaceutics2025

Microencapsulation of Probiotics for Enhanced Stability and Health Benefits in Dairy Functional Foods: A Focus on Pasta Filata Cheese.

Vita D'Amico, Mariasimona Cavaliere, Marianna Ivone, Chiara Lacassia, Giuseppe Celano, Mirco Vacca, Flavia Maria la Forgia, Sergio Fontana, Maria De Angelis, Nunzio Denora and 1 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  16. Double-layer microencapsulation ofBiotechnology reports (Amsterdam, Netherlands) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vita D'AmicoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 4, E. Orabona Street, 70125 Bari, Italy.ORCID 0009-0001-0385-8649
Mariasimona CavaliereDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 165/A, G. Amendola Street, 70126 Bari, Italy.
Marianna IvoneDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 4, E. Orabona Street, 70125 Bari, Italy.
Chiara LacassiaDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 4, E. Orabona Street, 70125 Bari, Italy.
Giuseppe CelanoDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 165/A, G. Amendola Street, 70126 Bari, Italy.ORCID 0000-0002-3805-7681
Mirco VaccaDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 165/A, G. Amendola Street, 70126 Bari, Italy.ORCID 0000-0003-0813-169X
Flavia Maria la ForgiaCentro Studi e Ricerche "Dr. S. Fontana 1900-1982", Farmalabor s.r.l., 47, Piano S. Giovanni Street, 76012 Canosa di Puglia, Italy.
Sergio FontanaCentro Studi e Ricerche "Dr. S. Fontana 1900-1982", Farmalabor s.r.l., 47, Piano S. Giovanni Street, 76012 Canosa di Puglia, Italy.
Maria De AngelisDepartment of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 165/A, G. Amendola Street, 70126 Bari, Italy.ORCID 0000-0002-2010-884X
Nunzio DenoraDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 4, E. Orabona Street, 70125 Bari, Italy.ORCID 0000-0002-7756-7828
Angela Assunta LopedotaDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, 4, E. Orabona Street, 70125 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics provide significant health benefits, but their viability is often compromised during production, storage, and passage through the gastrointestinal tract. These challenges hinder their effective incorporation into functional applications, particularly in dairy functional foods, in which factors such as acidity, oxygen exposure, and storage conditions negatively impact cell survival. The focus was on functional dairy foods, particularly on pasta filata cheeses. Indeed, the use of probiotics in pasta filata cheeses presents significant challenges due to the specific manufacturing processes, which encompass the application of high temperatures and other harsh conditions. These factors can adversely affect the viability and availability of probiotic microorganisms. However, microencapsulation has emerged as a promising solution, offering a protective barrier that enhances probiotic stability, improves survival rates, and facilitates targeted release in the gastrointestinal environment. This review examines the pivotal role of microencapsulation in stabilising probiotics for functional applications, emphasising its relevance in high-value food systems. Functional applications, including foods designed to offer essential nutritional benefits and promote host health, play a crucial role in disease prevention and immune system support, reducing the risk of infections and other physiological impairments. Key microencapsulation technologies are analysed, focusing on their benefits, limitations, and challenges related to scalability and industrial implementation. Additionally, this review discusses strategies to optimise formulations, ensure the sensory quality of final products, and explore future opportunities for expanding innovative applications that align with growing consumer demand for health-promoting solutions.

Indexed as

dairy functional foodsenhanced cell viabilitymicroencapsulation techniquespasta filataprebioticsprobioticssynbiotics

Identifiers

PMID40006552
PMCPMC11859715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.