Evidence map›Paper›PMID 40006060›Full record

ReviewPharmaceuticals (Basel, Switzerland)2025

Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications.

Juan Salazar, Ángel Ortega, José Luis Pérez, Bermary Garrido, Raquel Santeliz, Néstor Galbán, Maria Paula Díaz, Raquel Cano, Gabriel Cano, Julio Cesar Contreras-Velasquez and 1 more

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan SalazarEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0003-4211-528X
Ángel OrtegaEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0002-7180-4765
José Luis PérezEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0003-0914-5858
Bermary GarridoEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0002-5522-7697
Raquel SantelizEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0003-0761-5879
Néstor GalbánEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0003-0765-2290
Maria Paula DíazEndocrine and Metabolic Diseases Research Center, School of Medicine, University of Zulia, Maracaibo 4004, Venezuela.ORCID 0000-0001-6295-0229
Raquel CanoClínica General del Norte, Grupo de Estudio e Investigación en Salud, Barranquilla 080002, Colombia.ORCID 0000-0002-3692-9917
Gabriel CanoInstitut für Pharmazie Königin-Luise, Freie Universität Berlin, Strasse 2-4, 14195 Berlin, Germany.ORCID 0000-0003-2874-5330
Julio Cesar Contreras-VelasquezDepartamento de Productividad e Innovación, Universidad de la Costa, Barranquilla 080002, Colombia.ORCID 0000-0002-5179-5400
Maricarmen ChacínCentro de Investigaciones en Ciencias de la Vida (CICV), Facultad de Ciencias de la Salud, Universidad Simón Bolívar, Barranquilla 080002, Colombia.ORCID 0000-0002-5208-9401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although not frequently lethal, dermatological diseases represent a common cause of consultation worldwide. Due to the natural and non-invasive approach of phytotherapy, research for novel alternatives, such as polyphenols, to treat skin disorders is a subject of interest in modern medicine. Polyphenols, in particular, have been considered because of their anti-inflammatory, antitumoral, antimicrobial, and antioxidant properties, low molecular weight, and lipophilic nature that enables the passage of these compounds through the skin barrier. This review discusses the treatment of common dermatological diseases such as acne vulgaris, fungal infections, dermatitis, alopecia, and skin cancer, using polyphenols as therapeutic and prophylactic options. The specific molecules considered for each disorder, mechanisms of action, current clinical trials, and proposed applications are also reviewed.

Indexed as

phytotherapypolyphenolsskin disorders

Identifiers

PMID40006060
PMCPMC11859979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.