Evidence map›Paper›PMID 40006044›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Naringenin-Loaded Solid Lipid Nanoparticles: Physical-Chemical Characterization and In Vitro Antibacterial Activity.

Federica De Gaetano, Francesco Caridi, Noemi Totaro, Consuelo Celesti, Valentina Venuti, Giovanna Ginestra, Antonia Nostro, Silvana Tommasini, Cinzia Anna Ventura, Rosanna Stancanelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Mechanism, Efficacy, and Safety of Natural Antibiotics.Antibiotics (Basel, Switzerland) · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Federica De GaetanoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-9638-5520
Francesco CaridiDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-3562-6244
Noemi TotaroDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Consuelo CelestiDepartment of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, Italy.ORCID 0000-0003-1393-477X
Valentina VenutiDepartment of Mathematical and Computer Sciences, Physical Sciences and Earth Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0003-2907-9165
Giovanna GinestraDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Antonia NostroDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-4280-7895
Silvana TommasiniDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Cinzia Anna VenturaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8743-2046
Rosanna StancanelliDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-8670-7685

Funding

European Union (NextGeneration EU) through the MUR-PNRR project SAMOTHRACE ECS00000022
6 · The paper itself

Abstract

Currently, problems related to antibiotic resistance are shifting the focus of pharmaceutical research towards natural molecules with antibacterial properties. Among them, flavonoids represent promising molecules with strong antibacterial features; however, they have poor biopharmaceutical properties. In this study, we developed solid lipid nanoparticles (SLNs) loaded with the flavanone naringenin (NRG) to offer an option for treating bacterial infections. NRG-SLNs systems were prepared by a solvent emulsification/diffusion and ultrasonication method, using Compritol

Indexed as

biofilm inhibitionin vitro antibacterial activitynaringeninphysical–chemical characterizationsolid lipid nanoparticlestechnological characterization

Identifiers

PMID40006044
PMCPMC11859375

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.