Evidence map›Paper›PMID 40006022›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)?

Shaul Schreiber, Lee Keidan, Chaim G Pick

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shaul SchreiberDepartment of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0002-2189-0693
Lee KeidanSylvan Adams Sports Institute, Tel Aviv University, Tel Aviv 6905904, Israel.ORCID 0009-0004-1655-4793
Chaim G PickFaculty of Medicine & Health Sciences, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6905904, Israel.ORCID 0000-0001-7114-339X

Funding

Ari and Regine Aprijaskis Fund 347300-00Dr. Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases 601133461Sylvan Adams Sports Institute 0601133671
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

amisulprideantinociceptionmianserinmicemirtazapineopioidsreboxetinerisperidonetreatment-resistant depressionvenlafaxinezolpidem

Identifiers

PMID40006022
PMCPMC11858657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.