Evidence map›Paper›PMID 40006009›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells.

Marc Reina, Xavier Ariza, Dolors Serra, Jordi Garcia, Laura Herrero

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marc ReinaDepartment of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, E-08028 Barcelona, Spain.
Xavier ArizaDepartment of Inorganic and Organic Chemistry, School of Chemistry, Universitat de Barcelona, E-08028 Barcelona, Spain.ORCID 0000-0002-1479-3668
Dolors SerraDepartment of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, E-08028 Barcelona, Spain.
Jordi GarciaDepartment of Inorganic and Organic Chemistry, School of Chemistry, Universitat de Barcelona, E-08028 Barcelona, Spain.ORCID 0000-0001-9379-2577
Laura HerreroDepartment of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona, E-08028 Barcelona, Spain.ORCID 0000-0003-4244-4673

Funding

Government of Catalonia 2021SGR00367Ministerio de Ciencia, Innovación y Universidades 2021 FI_B 00572Ministerio de Ciencia, Innovación y Universidades PID2020-114953RB-C21Ministerio de Ciencia, Innovación y Universidades PID2023-148783OB-I00Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition CB06/03/0001
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe compound (±)-

methodsWe synthesized several (±)-

resultsOur results showed a decrease in cytotoxicity when the carbon chain was elongated by more than two carbons. However, ethyl or propyl polyhydroxylated four-branched compounds showed an increased or maintained potency and solubility. The most promising compound was (±)-

Indexed as

cancercytotoxicityfatty acid synthaseUB006

Identifiers

PMID40006009
PMCPMC11859419

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.