Initial Genome-Wide Case-Control Study for Genetic Background of Retinal Dysplasia in Czechoslovakian Wolfdog.

Michal Gábor, Juraj Candrák, Martina Miluchová, Pavol Zubrický, Agnieszka Balická, Alexandra Trbolová

Abstract read

In one paragraph

Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Michal GáborFaculty of Agrobiology and Food Resources, Institute of Nutrition and Genomics, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.ORCID 0000-0002-6623-6249

Juraj CandrákFaculty of Agrobiology and Food Resources, Institute of Nutrition and Genomics, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.

Martina MiluchováFaculty of Agrobiology and Food Resources, Institute of Nutrition and Genomics, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.ORCID 0000-0002-8945-3780

Pavol ZubrickýSmall Animal Clinic, University Veterinary Hospital, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

Agnieszka BalickáSmall Animal Clinic, University Veterinary Hospital, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.ORCID 0009-0007-4539-1497

Alexandra TrbolováSmall Animal Clinic, University Veterinary Hospital, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

Funding

Grant Agency VEGA 1/0194/22

6 · The paper itself

Abstract

Retinal dysplasia is a genetically heterogeneous ocular disorder in dogs, characterized by abnormal retinal development, resulting in a range of visual impairments from mild to complete blindness. The objective of this study was to investigate the prevalence and genetic basis of retinal dysplasia in the Czechoslovakian Wolfdog breed. An ophthalmic examination was conducted on a cohort of 117 Czechoslovakian Wolfdogs, which revealed a prevalence of multifocal retinal dysplasia of 5.13%. A genome-wide case-control association study was conducted on a subset of 36 adult dogs to explore the underlying genetic architecture of multifocal retinal dysplasia in this breed. The GWAS identified a suggestive association with a locus on canine chromosome CFA37. The strongest association signal for SNP marker BICF2G630130992 (

Indexed as

Czechoslovakian wolfdoggene CYP27A1GWAS analysisretinal dysplasia

Identifiers

PMID40005930

DOI10.3390/vetsci12020171

PMCPMC11860495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.