Evidence map›Paper›PMID 40005845›Full record

ReviewVeterinary sciences2025

Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review.

Munwar Ali, Chang Xu, Mingyue Wang, Qazal Hina, Yaru Ji, Subiha Anwar, Sijia Lu, Qing He, Yawei Qiu, Kun Li

Abstract readReview
In one paragraph

Review in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Current research in parasitology & vector-borne diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Munwar AliCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0009-0001-4480-5009
Chang XuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Mingyue WangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Qazal HinaDepartment of Animal Nutrition, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.ORCID 0009-0007-5908-8931
Yaru JiCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Subiha AnwarDepartment of Animal Husbandry, University of Agriculture, Faisalabad 38000, Pakistan.
Sijia LuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Qing HeCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Yawei QiuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.
Kun LiCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-2026-9969

Funding

This work was supported by the National Natural Science Foundation of China (32102692) 32102692
6 · The paper itself

Abstract

Cryptosporidiosis is a zoonotic protozoan parasite-born disease, equally significant in both animals and humans, especially affecting immunocompromised individuals (e.g., AIDS patients) and neonates. The prime concerns of this review article are to demonstrate the disruption of the intestinal barrier and variations in the gut microbiome during cryptosporidiosis, and to explore host gut-parasite interactions that can lead to the development of novel therapeutics. The review concluded that the enteric barrier is particularly maintained by tight junction proteins (e.g., occludin, claudin, and ZO-1, etc.) and mucosal immunity, both of which are severely compromised during

Indexed as

Cryptosporidiumgutintestinal barriermicrobiotaprotozoanzoonotic

Identifiers

PMID40005845
PMCPMC11861801

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.