ArticleVeterinary sciences2025
The Therapeutic Efficacy and Molecular Mechanisms of
Article in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
This study aimed to explore the therapeutic potential and mechanisms of Artemisia argyi essential oil (AAEO) in managing feline herpesvirus type 1 (FeHV-1) infections. FeHV-1, the causative agent of feline viral rhinotracheitis (FVR), leads to severe respiratory and systemic complications in cats. In this study, 35 cats were divided into blank, FeHV-1 infection, and AAEO treatment groups (high, medium, and low doses). In vivo experiments demonstrated that AAEO alleviated clinical symptoms, reduced tissue damage, and modulated immune responses. The AAEO-treated groups showed higher survival rates, stabilized body temperatures, and less severe weight loss compared to the FeHV-1 group. Histopathological analysis revealed improved integrity in nasal, tracheal, and bronchial tissues. Transcriptomic and proteomic analyses identified critical pathways, such as IL-17 signaling, influenced by AAEO treatment, highlighting its role in suppressing inflammation and protecting tissue integrity. In vitro assays revealed that AAEO has concentration-dependent cytotoxicity in feline kidney cells (F81) and provides protective effects when used as a pre-treatment. These findings suggest that AAEO enhances host immune defenses and mitigates FeHV-1-induced damage through immune modulation and tissue protection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.