Evidence map›Paper›PMID 40005824›Full record

ReviewMicroorganisms2025

Leveraging Microorganisms to Combat Skin Cancer.

Hayden J Oyler, Austen W Callister, Makenzi N Kutch, Mark R Wakefield, Yujiang Fang

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hayden J OylerDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.ORCID 0009-0008-4790-1945
Austen W CallisterSpencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Makenzi N KutchDepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USA.
Mark R WakefieldDepartment of Surgery, School of Medicine, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0003-2598-7895
Yujiang FangDepartment of Microbiology, Immunology & Pathology, Des Moines University, West Des Moines, IA 50266, USA.

Funding

Dr. Yujiang Fang IOER 112-3119
6 · The paper itself

Abstract

Skin cancer, including melanoma and non-melanoma types, presents a significant and growing global health challenge due to its increasing incidence and mortality rates. While conventional treatments such as surgical excision, immunotherapy, and targeted therapies are well-established, microorganism-based approaches represent an innovative and promising alternative. These therapies employ live, genetically engineered, or commensal bacteria, viral vectors, or bacterial components to achieve various therapeutic mechanisms, including tumor targeting, immune system modulation, vascular disruption, competitive exclusion, drug delivery, and direct oncolysis. Despite their potential, these approaches require further investigation to address safety concerns, optimize treatment protocols, and gain a comprehensive understanding of their long-term outcomes.

Indexed as

microorganism cancer treatmentnanocarriersoncolytic virusesprobioticsskin cancer treatmentskin microbiota

Identifiers

PMID40005824
PMCPMC11858759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.