ArticleMicroorganisms2025
Hesperetin Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Downregulating the P38/JUN/FOS Pathway In Vitro.
Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integration of ATAC-seq and RNA-seq analysis identifies host genes related with PRRSV infection.Veterinary research · 2026Article
- Verapamil HCl demonstrates antiviral activity against porcine reproductive and respiratory syndrome virus by regulating CaMicrobiology spectrum · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is a persistent pathogen that causes significant economic losses to the global swine industry. Commercial vaccines provide only partial protection, and no effective therapeutic treatments are currently available. In this study, we demonstrate that hesperetin (Hst), a flavonoid glycoside derived from orange and tangerine peels, inhibits PRRSV replication in a dose-dependent manner in Marc-145 and PAMs cells. Transcriptome analysis further reveals that the anti-PRRSV effects of Hst are associated with the suppression of the P38 MAPK pathway, as Hst significantly downregulates key genes, including NRA41, JUN, FOS, and DUSP1. Subsequent investigations show that Hst inhibits PRRSV replication by downregulating the P38/JUN/FOS signaling cascade. These findings offer valuable insights for the development of novel preventive and therapeutic strategies against PRRSV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.