Evidence map›Paper›PMID 40005762›Full record

ArticleMicroorganisms2025

Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant

Natália Ferreira de Sousa, Maria Eugênia G de Freitas, Maria Gabriella S Sidrônio, Helivaldo Diógenes Souza, Alexia Czeczot, Marcia Perelló, Gabriela Fehn Fiss, Luciana Scotti, Demétrius A M de Araújo, José Maria Barbosa Filho and 7 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Natália Ferreira de SousaGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-7131-6414
Maria Eugênia G de FreitasLaboratory of Biotechnology in Microorganisms, Biotechnology Center, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.
Maria Gabriella S SidrônioGraduate Program in Development and Technological Innovation in Medicines, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.
Helivaldo Diógenes SouzaGraduate Program in Chemistry, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-1708-4066
Alexia CzeczotPrograma de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)-Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), PUCRS, Porto Alegre 90619-900, RS, Brazil.
Marcia PerellóPrograma de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)-Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), PUCRS, Porto Alegre 90619-900, RS, Brazil.
Gabriela Fehn FissGraduate Program in Chemistry, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-8156-2272
Luciana ScottiGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-1866-4107
Demétrius A M de AraújoGraduate Program in Biotechnology (Renorbio), Department of Biotechnology, Biotechnology Center, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-7320-7203
José Maria Barbosa FilhoGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.
Cristiano V BizarroPrograma de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)-Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), PUCRS, Porto Alegre 90619-900, RS, Brazil.ORCID 0000-0002-2609-8996
Pablo MachadoPrograma de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)-Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), PUCRS, Porto Alegre 90619-900, RS, Brazil.ORCID 0000-0001-5616-9583
Luiz Augusto BassoPrograma de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)-Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF), PUCRS, Porto Alegre 90619-900, RS, Brazil.
Francisco Jaime B Mendonça-JuniorGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-3588-833X
Petrônio F de Athayde FilhoGraduate Program in Chemistry, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.
Marcus T ScottiGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-4863-8057
Valnês S Rodrigues-JuniorGraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-4849-2249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selene-ethylenelacticamide derivatives have been suggested as promising scaffolds with leishmanicidal activity. In this work, we demonstrated, for the first time, the effectiveness of selene-ethylenelacticamide derivatives against mycobacteria. Firstly, selene-ethylenelacticamides inhibited the growth of laboratory strains of

Indexed as

dormancydrug developmentresistanceselene-ethylenelacticamidestoxicitytuberculosis

Identifiers

PMID40005762
PMCPMC11858155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.