Evidence map›Paper›PMID 40005720›Full record

ArticleMicroorganisms2025

Genetic Code Expansion for Controlled Surfactin Production in a High Cell-Density

Alexander Hermann, Eric Hiller, Philipp Hubel, Lennart Biermann, Elvio Henrique Benatto Perino, Oscar Paul Kuipers, Rudolf Hausmann, Lars Lilge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander HermannDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.
Eric HillerDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.ORCID 0009-0000-3815-920X
Philipp HubelCore Facility Hohenheim, Mass Spectrometry Core Facility, University of Hohenheim, 70599 Stuttgart, Germany.
Lennart BiermannDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.ORCID 0009-0005-9773-0783
Elvio Henrique Benatto PerinoDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.ORCID 0000-0003-0372-260X
Oscar Paul KuipersDepartment of Molecular Genetics, University of Groningen, 9747 AG Groningen, The Netherlands.ORCID 0000-0001-5596-7735
Rudolf HausmannDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.ORCID 0000-0002-2327-7120
Lars LilgeDepartment of Bioprocess Engineering, Institute of Food Science and Biotechnology, University of Hohenheim, 70599 Stuttgart, Germany.ORCID 0000-0002-7693-477X

Funding

Federal Ministry of Education and Research 031B1059FGerman Research Foundation 501222601German Research Foundation 501222797German Research Foundation DFG-INST 36/171-1 FUGG
6 · The paper itself

Abstract

backgroundIn biotechnology,

methodsIntegration of an amber stop codon into the

resultsUsing a surfactin-forming

conclusionsThe principle of genetic code expansion enabled a precise control of the surfactin bioproduction as a representative of bioactive secondary metabolites in

Indexed as

Bacillus subtilisbioprocess engineeringbioreactorbiosurfactantsgenetic code expansionmolecular adaptationnon-canonical amino acidproteomicssurfactin

Identifiers

PMID40005720
PMCPMC11858380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.