Evidence map›Paper›PMID 40005693›Full record

ArticleMicroorganisms2025

Microbial Changes Occurring During Oronasal Fistula Wound Healing.

Steven L Goudy, Heath L Bradley, Camilo Anthony Gacasan, Afra Toma, Keerthi Priya Chinniampalayam Sekar, William M Wuest, Martin Tomov, Vahid Serpooshan, Ahmet Coskun, Rheinallt M Jones

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In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Steven L GoudyDepartment of Otolaryngology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.
Heath L BradleyDepartment of Otolaryngology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.
Camilo Anthony GacasanDepartment of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.ORCID 0000-0003-2527-9207
Afra TomaDepartment of Otolaryngology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.ORCID 0000-0002-0383-046X
Keerthi Priya Chinniampalayam SekarDepartment of Otolaryngology, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.
William M WuestDepartment of Chemistry, Emory University, Atlanta, GA 30329, USA.ORCID 0000-0002-5198-7744
Martin TomovDepartment of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.
Vahid SerpooshanDepartment of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.ORCID 0000-0002-5304-095X
Ahmet CoskunDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-5797-1524
Rheinallt M JonesDepartment of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA 30329, USA.ORCID 0000-0002-0415-9487

Funding

Determining Host-microbiome guided oro-nasal fistula healingR21DE030632 · NIDCR · EMORY UNIVERSITY · PI GOUDY, STEVEN L, JONES, RHEINALLT MELFYN · 2022 to 2023
$430k
NIDCR NIH HHS R21 DE030632NIH HHS 1C06DE030632-02A1
6 · The paper itself

Abstract

The oral microbiome is a complex community that matures with dental development and is recognized as a risk factor for systemic disease. Despite the oral cavity having a substantial microbial burden, healing of superficial oral wounds occurs quickly and with little scarring. By contrast, creation of an oro-nasal fistula (ONF), often occurring after surgery to correct a cleft palate, is a significant wound healing challenge.

methodsIn this study, we characterized the changes in the oral microbiome of mice following a freshly inflicted wound in the oral palate that results in an open and unhealed ONF.

resultsCreation of an ONF in mice significantly lowered oral microbiome alpha diversity, with concurrent blooms of

conclusionsAn ONF in the murine palate leads to a dysbiotic oral microbiome and a bloom of opportunistic pathogens that may prevent ONF healing. Delivery of therapeutics that accelerate ONF healing might restore oral microbiome diversity and inhibit blooms of opportunistic pathogens.

Indexed as

antibioticsoral microbiomeoro-nasal fistula (ONF)

Identifiers

PMID40005693
PMCPMC11857856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.