Evidence map›Paper›PMID 40005688›Full record

ArticleMicroorganisms2025

Drug Resistance Mutations (DRMs) for Long-Acting Injectable Cabotegravir and Rilpivirine (CAB/RPV LAI) in the HIV-1 Subtype A6 Epidemic in Poland.

Andrzej Załęski, Agnieszka Lembas, Tomasz Dyda, Joanna Osińska, Joanna Jabłońska, Justyna Stempkowska-Rejek, Justyna Orzechowska, Alicja Wiercińska-Drapało

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrzej ZałęskiHospital for Infectious Diseases in Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.ORCID 0000-0001-8257-2739
Agnieszka LembasHospital for Infectious Diseases in Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.ORCID 0000-0003-3920-1670
Tomasz DydaMolecular Diagnostics Laboratory, Hospital for Infectious Diseases in Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.
Joanna OsińskaInfectious Diseases Clinical Ward in Ostróda, Department of Family Medicine and Infectious Diseases, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2 Street, 10-719 Olsztyn, Poland.
Joanna JabłońskaHospital for Infectious Diseases in Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.
Justyna Stempkowska-RejekDepartment of Infectious Diseases and Hepatology, Medical University of Lublin, Aleje Racławickie 1 Street, 20-059 Lublin, Poland.ORCID 0000-0003-2938-117X
Justyna OrzechowskaClinical Department of Infectious Diseases, Medical Center in Łańcut, College of Medical Sciences, University of Rzeszów, Rejtana 16c Street, 35-310 Rzeszów, Poland.
Alicja Wiercińska-DrapałoHospital for Infectious Diseases in Warsaw, Wolska 37 Street, 01-201 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV subtype A6 with the L74I polymorphism, which increases the risk of cabotegravir/rilpivirine treatment failure, causes more and more infections in Poland. In this multicenter, observational, cross-sectional study (2023-2024), we analyzed viral subtypes and drug-resistance mutations to drugs used for long-acting injectable antiretroviral treatment and pre-exposure prophylaxis. Among 357 people with HIV, 247 (69%) were Polish nationals, and 102 (29%) were from former Soviet Union countries. Of the 357 people included, 159 (45%) had subtype B, and 177 (50%) had subtype A6 infections, with 165 (87%) of the latter characterized by the L74I polymorphism. Subtype A6 was more frequent in women (66% vs. 46% in men,

Indexed as

A6ARTCAB/RPVDRMsdrug resistanceHIV subtypeLAI

Identifiers

PMID40005688
PMCPMC11858022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.