Pathogenicity of Highly Pathogenic Avian Influenza A/H5Nx Viruses in Avian and Murine Models.

Sara H Mahmoud, Marwa S Khattab, Nahed Yehia, Ali Zanaty, Abd El Sattar Arafa, Ahmed A Khalil

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara H MahmoudCenter of Scientific Excellence for Influenza Viruses (CSEIV), National Research Centre (NRC), Dokki, Giza 12622, Egypt.

Marwa S KhattabPathology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.

Nahed YehiaReference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Center, Dokki, Giza 12618, Egypt.ORCID 0000-0002-2823-6467

Ali ZanatyReference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Center, Dokki, Giza 12618, Egypt.ORCID 0000-0003-3229-4069

Abd El Sattar ArafaReference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Center, Dokki, Giza 12618, Egypt.

Ahmed A KhalilVeterinary Serum and Vaccine Research Institute (VSVRI), Agriculture Research Center (ARC), Cairo 11381, Egypt.ORCID 0000-0002-2920-1178

Funding

National Strategy for Genetic Engineering and Biotechnology, Academy of Scientific Research and Technology (ASRT), Egypt 80/2021

6 · The paper itself

Abstract

The evolution and adaptation of highly pathogenic avian influenza (HPAI) viruses pose ongoing challenges for animal and public health. We investigated the pathogenic characteristics of the newly emerged H5N1/2022 and H5N8/2022 of clade 2.3.4.4b compared to the previously circulating H5N1/2016 of clade 2.2.1.2 in Egypt using both avian and murine models. All strains demonstrated a 100% mortality in chickens after intranasal inoculation (10

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza A Virus, H5N8 SubtypeInfluenza in BirdsOrthomyxoviridae InfectionsAnimalsChickensDisease Models, AnimalEgyptMiceVirulenceVirus ReplicationVirus Sheddingavian influenza virusesH5Nxpathogenicitytransmissibility

Identifiers

PMID40005526

DOI10.3390/pathogens14020149

PMCPMC11858509

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.