Evidence map›Paper›PMID 40005515›Full record

ArticlePathogens (Basel, Switzerland)2025

Putrescine Depletion in

Julia Johnston, Jonathan Taylor, Surbhi Nahata, Angelica Gatica-Gomez, Yvette L Anderson, Sophia Kiger, Thong Pham, Kayhan Karimi, Jasmin-Faith Lacar, Nicola S Carter and 1 more

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. In Silico Screening ofBiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia JohnstonSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.ORCID 0009-0008-0554-1312
Jonathan TaylorSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.ORCID 0000-0002-4121-967X
Surbhi NahataSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Angelica Gatica-GomezSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Yvette L AndersonSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Sophia KigerSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Thong PhamSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Kayhan KarimiSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Jasmin-Faith LacarSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.
Nicola S CarterSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.ORCID 0000-0003-4720-1582
Sigrid C RobertsSchool of Pharmacy, Pacific University, Hillsboro, OR 97123, USA.ORCID 0000-0002-0964-8554

Funding

Elucidating the Functions of the Essential Polyamine Putrescine for Proliferation and Survival of Leishmania ParasitesR15AI151980 · NIAID · PACIFIC UNIVERSITY · PI ROBERTS, SIGRID CHRISTIANE · 2021 to 2021
$377k
NIAID NIH HHS R15 AI151980NIH HHS 1R15AI151980-04A1
6 · The paper itself

Abstract

The polyamine pathway in

Indexed as

ApoptosisLeishmania donovaniPutrescineAnimalsCell ProliferationMiceMitochondriaOrnithine DecarboxylasePolyaminesSpermidine SynthaseOrnithine DecarboxylasePolyaminesPutrescineSpermidine SynthaseapoptosisLeishmaniamitochondriaornithine decarboxylasepolyaminesreplicationspermidine synthasestarvation

Identifiers

PMID40005515
PMCPMC11858418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.