Evidence map›Paper›PMID 40005509›Full record

ArticlePathogens (Basel, Switzerland)2025

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector.

Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingjing ZhangSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Mengfei WangBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China.
Dan WangBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China.
Xiangyi ZhangBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102206, China.
Yue MaDepartment of Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503, USA.ORCID 0000-0002-1031-5175
Els PardonVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, 1050 Brussels, Belgium.ORCID 0000-0002-2466-0172
Jan SteyaertVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, 1050 Brussels, Belgium.
Romany AbskharonVIB-VUB Center for Structural Biology, VIB, Pleinlaan 2, 1050 Brussels, Belgium.ORCID 0000-0003-1350-0189
Fei WangDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Jiyan MaSchool of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0001-7150-1898

Funding

Creutzfeldt-Jakob Disease foundation 2019
6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrP

Indexed as

DependovirusGenetic VectorsPrion DiseasesPrion ProteinsPrPC ProteinsSingle-Domain AntibodiesAnimalsAnimals, NewbornBrainDisease Models, AnimalGenetic TherapyHumansInjections, IntraventricularMicePrion ProteinsPrPC ProteinsSingle-Domain Antibodiesadeno-associated virusnanobodypriontherapytransmissible spongiform encephalopathy

Identifiers

PMID40005509
PMCPMC11858434

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.