Evidence map›Paper›PMID 40005505›Full record

ArticlePathogens (Basel, Switzerland)2025

Repurposing COVID-19 Compounds (via MMV COVID Box): Almitrine and Bortezomib Induce Programmed Cell Death in

Carlos J Bethencourt-Estrella, Atteneri López-Arencibia, Jacob Lorenzo-Morales, José E Piñero

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos J Bethencourt-EstrellaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Spain.
Atteneri López-ArencibiaInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Spain.ORCID 0000-0002-0675-8221
Jacob Lorenzo-MoralesInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Spain.
José E PiñeroInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez, S/N, 38203 La Laguna, Spain.

Funding

Cabildo de Tenerife CC20230222, CABILDO.23Centro de Investigación Biomédica en Red CB21/13/00100Fundación CajaCanarias 2022CLISA26Instituto de Salud Carlos III PMP22/00092
6 · The paper itself

Abstract

Chagas disease, caused by the protozoan

Indexed as

ApoptosisBortezomibCOVID-19 Drug TreatmentDrug RepositioningTrypanocidal AgentsTrypanosoma cruziAnimalsChagas DiseaseCOVID-19HumansMiceReactive Oxygen SpeciesSARS-CoV-2BortezomibReactive Oxygen SpeciesTrypanocidal AgentsapoptosischemotherapyCOVID BoxMMVTrypanosoma cruzi

Identifiers

PMID40005505
PMCPMC11858128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.