Evidence map›Paper›PMID 40005451›Full record

ArticleMedicina (Kaunas, Lithuania)2025

Ameliorative Effect of N-Acetylcysteine Against 5-Fluorouracil-Induced Cardiotoxicity via Targeting TLR4/NF-κB and Nrf2/HO-1 Pathways.

Omer Abdelbagi, Medhat Taha, Abdullah G Al-Kushi, Mohammad Ahmad Alobaidy, Tourki A S Baokbah, Hatem A Sembawa, Zohor Asaad Azher, Rami Obaid, Omar Babateen, Bayan T Bokhari and 2 more

Abstract read
In one paragraph

Article in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Omer AbdelbagiDepartment of Pathology, Qunfudah Faculty of Medicine, Umm Al-Qura University, Al-Qunfudhah 28814, Saudi Arabia.ORCID 0000-0001-8307-6286
Medhat TahaDepartment of Anatomy, Al-Qunfudah Medical College, Umm Al-Qura University, Al-Qunfudhah 28814, Saudi Arabia.ORCID 0000-0001-8440-5002
Abdullah G Al-KushiDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Mohammad Ahmad AlobaidyDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0002-6911-9179
Tourki A S BaokbahDepartment of Medical Emergency Services, College of Health Sciences-AlQunfudah, Umm Al-Qura University, Al-Qunfudhah 28814, Saudi Arabia.ORCID 0000-0001-6091-198X
Hatem A SembawaDepartment of Surgery, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0003-0204-2696
Zohor Asaad AzherDepartment of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0009-0004-2672-5496
Rami ObaidDepartment of Medical Genetics, Faculty of Medicine at Al-Qunfudah, Umm Al-Qura University, Al-Qunfudhah 28814, Saudi Arabia.
Omar BabateenDepartment of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Bayan T BokhariDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24382, Saudi Arabia.
Naeem F QustyDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0003-4662-6706
Hesham A MalakDepartment of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah 24382, Saudi Arabia.ORCID 0000-0001-5101-8348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetylcysteineCardiotoxicityFluorouracilAnimalsMaleNF-E2-Related Factor 2NF-kappa BOxidative StressRatsRats, WistarSignal TransductionToll-Like Receptor 4AcetylcysteineFluorouracilNfe2l2 protein, ratNF-E2-Related Factor 2NF-kappa BTlr4 protein, ratToll-Like Receptor 45-fluorouracilapoptosiscardiotoxicityinflammationN-acetylcysteineoxidative stress

Identifiers

PMID40005451
PMCPMC11857307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.