Evidence map›Paper›PMID 40005443›Full record

ReviewMedicina (Kaunas, Lithuania)2025

An Updated Review on the Use of Noninvasive Respiratory Supports in the Management of Severe Asthma Exacerbations.

Giuseppe Cuttone, Luigi La Via, Federico Pappalardo, Massimiliano Sorbello, Daniele Salvatore Paternò, Matteo Piattoli, Cesare Gregoretti, Giovanni Misseri

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppe CuttoneDepartment of Anaesthesia and Trauma Center, Azienda Ospedaliera "Ospedali Riuniti Villa Sofia-Cervello", 90146 Palermo, Italy.ORCID 0009-0005-5271-1810
Luigi La ViaDepartment of Anaesthesia and Intensive Care 1, University Hospital Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.ORCID 0000-0002-2156-7554
Federico PappalardoFaculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Massimiliano SorbelloFaculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0000-0002-9331-2788
Daniele Salvatore PaternòDepartment of Anaesthesia and Intensive Care, Giovanni Paolo II Hospital, 97100 Ragusa, Italy.ORCID 0009-0003-0215-5620
Matteo PiattoliFaculty of Medicine and Dentistry, Università degli Studi di Roma "La Sapienza", 00185 Rome, Italy.ORCID 0000-0002-2156-0088
Cesare GregorettiFaculty of Medicine and Surgery, Saint Camillus International University of Health and Medical Sciences "UniCamillus", 00131 Rome, Italy.
Giovanni MisseriDepartment of Anaesthesia and Intensive Care, Fondazione Istituto "G. Giglio" Cefalù, 90015 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is a reversible clinical condition characterized by airway obstruction due to bronchial smooth muscle contraction, inflammation and a hypersecretive state. Severe asthma exacerbations (SAE) may be a part of the natural history of this condition. Patients presenting with SAE are at higher risk of recurrent attacks, often nonresponsive to medical therapy and eventually requiring invasive mechanical ventilation (MV). The use of noninvasive respiratory supports (NRSs) may be beneficial in patients with SAE who are at risk of developing acute respiratory failure (ARF). However, their application is insufficiently supported by the evidence, as reports on their application in asthmatic patients are scarce and only a few retrospective studies with a limited number of participants have been published to date. This review discusses the potentialities of NRS in the treatment of SAE, with reference to the pathophysiological background and future perspectives on their use in asthma management.

Indexed as

AsthmaNoninvasive VentilationDisease ProgressionHumansRespiratory Insufficiencyacute respiratory failureARFasthmaCPAPHFNOThigh flow nasal cannulamechanical ventilationNIVnoninvasive intermittent positive pressure ventilationnoninvasive ventilationNPPVstatus asthmaticus

Identifiers

PMID40005443
PMCPMC11857382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.