Evidence map›Paper›PMID 40005270›Full record

ReviewMolecules (Basel, Switzerland)2025

Anticancer Activity of Ether Derivatives of Chrysin.

Arkadiusz Sokal, Patryk Mruczek, Mateusz Niedoba, Agnieszka Dewalska, Klaudia Stocerz, Monika Kadela-Tomanek

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arkadiusz SokalDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.ORCID 0009-0000-5299-317X
Patryk MruczekDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland.ORCID 0009-0009-8389-177X
Mateusz NiedobaDoctoral School, Medical University of Silesia in Katowice, 15 Poniatowskiego Str., 40-055 Katowice, Poland.ORCID 0009-0004-3561-8684
Agnieszka DewalskaDoctoral School, Medical University of Silesia in Katowice, 15 Poniatowskiego Str., 40-055 Katowice, Poland.ORCID 0000-0002-1113-8051
Klaudia StocerzDoctoral School, Medical University of Silesia in Katowice, 15 Poniatowskiego Str., 40-055 Katowice, Poland.ORCID 0009-0001-9965-8851
Monika Kadela-TomanekDepartment of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 30 Ostrogórska Str., 41-200 Sosnowiec, Poland.ORCID 0000-0001-9045-5428

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chrysin, a naturally occurring flavonoid, exhibits a broad spectrum of biological activities, including showing anticancer properties. However, its clinical application is limited by poor bioavailability and low solubility. The introduction of an amine, amide, ester, or alkoxy group to a flavone skeleton influences the biological activity. This review also discusses hybrid compounds, such as the chrysin-porphyrin hybrid, which are characterized by higher biological activity and better bioavailability properties than single molecules. This review concentrates on the anticancer activity of chrysin and its derivatives against the most popular cancers, such as breast, lung, prostate, and gastrointestinal tumors.

Indexed as

Antineoplastic AgentsEthersFlavonoidsNeoplasmsAnimalsHumansMolecular StructureAntineoplastic AgentschrysinEthersFlavonoidsanticancerchrysinchrysin derivatives

Identifiers

PMID40005270
PMCPMC11857933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.