Evidence map›Paper›PMID 40005266›Full record

ArticleMolecules (Basel, Switzerland)2025

Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL.

Christine Rossmann, Azra Darko, Gerd Kager, Gerhard Ledinski, Willibald Wonisch, Thomas Wagner, Seth Hallström, Gilbert Reibnegger, Margret Paar, Gerhard Cvirn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christine RossmannDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Azra DarkoDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Gerd KagerDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Gerhard LedinskiDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Willibald WonischDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-7171-9539
Thomas WagnerDepartment of Blood Group Serology and Transfusion Medicine, Medical University of Graz, 8010 Graz, Austria.
Seth HallströmDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Gilbert ReibneggerDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Margret PaarDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0001-5494-8890
Gerhard CvirnDivision of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-1410-1844

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis. In our in vitro-model, LDL oxidation was induced by the addition of CuCl

Indexed as

Lipoproteins, LDLSpermidineCell LineHumansLipid PeroxidationOxidation-ReductionLipoproteins, LDLoxidized low density lipoproteinSpermidineantioxidantsatherogenesiscopper ionsendothelial damagelipid oxidation

Identifiers

PMID40005266
PMCPMC11858627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.