Evidence map›Paper›PMID 40005260›Full record

ArticleMolecules (Basel, Switzerland)2025

The Production and Characterization of an Aminolyzed Polyhydroxyalkanoate Membrane and Its Cytocompatibility with Osteoblasts.

Qiulan Luo, Fuming Zou, Dongjuan Yang, Yongping Huang, Dajie Xian, Ying Nie, Zhenxia Zhang, Yuzhong Zheng, Yaqun Liu, Fei Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qiulan LuoGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.ORCID 0000-0001-7103-3465
Fuming ZouGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Dongjuan YangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Yongping HuangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Dajie XianGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Ying NieGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Zhenxia ZhangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Yuzhong ZhengGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Yaqun LiuGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Fei ZhouGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Peikui YangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Yuting JiangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Xianjing HuangGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.
Xianghui ZouGuangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, School of Life Sciences and Food Engineering, Hanshan Normal University, Chaozhou 521041, China.ORCID 0009-0002-4065-0588

Funding

Collaborative Innovation Research Center for Nutrition and Functional Food 622006Doctoral scientific research foundation of Hanshan normal university E22049Guangdong Natural Science Foundation 2024A1515010278Guangdong Provincial Department of Education's Characteristic Innovation Project 2023KTSCX084Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products 2021B1212040015Quality engineering construction project for undergraduate universities of Guangdong Province E23026Special Projects in Key Areas for the Universities of Guangdong Province 2022ZDZX4030The Key Technology of High Pressure Juice Preparation and its Applied Research XSB202401
6 · The paper itself

Abstract

Polyhydroxyalkanoates (PHAs), recognized as a medical biomaterial, have been proven to promote cell proliferation and tissue repair. PHA has a variety of forms: PHB, PHV, PHHx, and PHBHHx, etc. In this study, PHBHHx was selected as the precursor to fabricate biopolyester films. Specifically, a novel type of biopolyester film was generated through an ammonolysis cross-linking reaction in conjunction with polyamidoamine dendrimer G2.0 (PAMAM). The properties of the resultant biopolyester films were comprehensively evaluated, encompassing surface characteristics, amino group content, and water contact angle. The drug-loading properties and compatibility with osteoblasts of the biopolyester films were also determined. The findings revealed that following aminolysis, the biopolyester film surface exhibited enhanced roughness and an enlarged surface area. Moreover, as the aminolysis duration extended, the hydrophilicity and drug-loading efficiency were significantly augmented. Post-aminolysis, the PHBHHx membrane exhibited a more favorable environment for the adhesion and proliferation of osteoblasts. Overall, the biopolyester film developed in this study provides novel insights and materials for tissue engineering, especially bone tissue repair.

Indexed as

Biocompatible MaterialsOsteoblastsPolyhydroxyalkanoatesAnimalsCell AdhesionCell ProliferationDendrimersHumansMaterials TestingMiceSurface PropertiesTissue EngineeringBiocompatible MaterialsDendrimersPolyhydroxyalkanoatesammonolysis reactionbiopolyester filmcytocompatibilityosteoblastpoly-3-hydroxybutyrate-co-3-hydroxyhexanoate

Identifiers

PMID40005260
PMCPMC11858010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.