Evidence map›Paper›PMID 40005231›Full record

ReviewMolecules (Basel, Switzerland)2025

Promising Natural Remedies for Alzheimer's Disease Therapy.

Amin Mahmood Thawabteh, Aseel Wasel Ghanem, Sara AbuMadi, Dania Thaher, Weam Jaghama, Donia Karaman, Rafik Karaman

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Virosomes: Beyond Vaccines.Life (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Evaluation of Immunoprotective Activities of White Button Mushroom (Animals : an open access journal from MDPI · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Potential therapeutic effects of Ebixa,Frontiers in neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amin Mahmood ThawabtehDepartment of Chemistry, Birzeit University, West Bank, Ramallah 00972, Palestine.ORCID 0000-0002-0672-9439
Aseel Wasel GhanemFaculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine.ORCID 0009-0006-8634-207X
Sara AbuMadiFaculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine.ORCID 0009-0008-1274-402X
Dania ThaherFaculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine.
Weam JaghamaFaculty of Pharmacy, Nursing and Health Professions, Birzeit University, West Bank, Ramallah 00972, Palestine.ORCID 0000-0001-7852-1621
Donia KaramanPharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem 20002, Palestine.
Rafik KaramanPharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem 20002, Palestine.ORCID 0000-0001-5526-4490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the intricacies of Alzheimer's disease (AD), its origins, and the potential advantages of various herbal extracts and natural compounds for enhancing memory and cognitive performance. Future studies into AD treatments are encouraged by the review's demonstration of the effectiveness of phytoconstituents that were extracted from a number of plants. In addition to having many beneficial effects, such as improved cholinergic and cognitive function, herbal medicines are also much less harmful, more readily available, and easier to use than other treatments. They also pass without difficulty through the blood-brain barrier (BBB). This study focused on natural substances and their effects on AD by using academic databases to identify peer-reviewed studies published between 2015 and 2024. According to the literature review, 66 phytoconstituents that were isolated from 21 distinct plants have shown efficacy, which could be encouraging for future research on AD therapies. Since most clinical trials produce contradictory results, the study suggests that larger-scale studies with longer treatment durations are necessary to validate or refute the therapeutic efficacy of herbal AD treatments.

Indexed as

Alzheimer DiseaseBiological ProductsPlant ExtractsAnimalsBlood-Brain BarrierHumansPhytotherapyPlants, MedicinalBiological ProductsPlant ExtractsAlzheimer’s diseaseanti-amyloid drugsGinkgo bilobaphytoconstituentsrosemary

Identifiers

PMID40005231
PMCPMC11858286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.