Evidence map›Paper›PMID 40005201›Full record

ArticleMolecules (Basel, Switzerland)2025

Algal Lectin Griffithsin Inhibits Ebola Virus Infection.

Leah Liu Wang, Kendra Alfson, Brett Eaton, Marc E Mattix, Yenny Goez-Gazi, Michael R Holbrook, Ricardo Carrion, Shi-Hua Xiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leah Liu WangNebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Kendra AlfsonTexas Biomedical Research Institute, 8715 W. Military Drive, San Antonio, TX 78227, USA.ORCID 0000-0001-6031-5360
Brett EatonIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, Frederick, MD 21702, USA.
Marc E MattixNonclinical Pathology Services, LLC, 5920 Clubhouse Pointe Dr., Medina 44256, OH, USA.
Yenny Goez-GaziTexas Biomedical Research Institute, 8715 W. Military Drive, San Antonio, TX 78227, USA.
Michael R HolbrookIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, Frederick, MD 21702, USA.ORCID 0000-0002-0824-2667
Ricardo CarrionTexas Biomedical Research Institute, 8715 W. Military Drive, San Antonio, TX 78227, USA.
Shi-Hua XiangNebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.ORCID 0000-0002-5656-5698

Funding

Structure-Based Design of Peptide Entry Inhibitors against Ebola Virus InfectionR21AI151483 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI XIANG, SHI-HUA · 2021 to 2022
$468k
NIAID NIH HHS HHSN272201800013CNIAID NIH HHS R21 AI151483NIH HHS R21AI151483 (SHX); HHSN272201800013C(MRH)
6 · The paper itself

Abstract

Algal lectin Griffithsin (GRFT) is a well-known mannose-binding protein which has broad-spectrum antiviral activity against several important infectious viruses including HIV, HCV, and SARS-CoV-2. Therefore, GRFT has been brought great attention to antiviral therapeutic development. In this report, we have tested GRFT's activity against the lethal Ebola virus

Indexed as

Antiviral AgentsEbolavirusHemorrhagic Fever, EbolaLectinsPlant LectinsAnimalsChlorocebus aethiopsDisease Models, AnimalHumansMicePolysaccharidesVero CellsAntiviral Agentsgriffithsin protein, GriffithsiaLectinsPlant LectinsPolysaccharidesalgal lectincarbohydrate-bindingEbola virus disease (EVD)Ebola virus (EBOV)griffithsin (GRFT)mannose-binding

Identifiers

PMID40005201
PMCPMC11858388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.