ArticleMolecules (Basel, Switzerland)2025
Maia Zeni, Maria Daniela Santi, Florencia Arredondo, Laura Reyes, Manuela Bentura, Diego Carvalho, Mariana Peralta, Maria Gabriela Ortega, Juan A Abin-Carriquiry, Loreto Martínez-Gonzalez and 5 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Maia ZeniGraduate Program in Chemistry, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.ORCID 0009-0006-7011-0258 Maria Daniela SantiCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.ORCID 0000-0002-3866-1424 Florencia ArredondoCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.
Laura ReyesCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.ORCID 0009-0005-5965-6906 Manuela BenturaCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.ORCID 0009-0000-2909-749X Diego CarvalhoInstituto de Investigaciones Biológicas "Clemente Estable" (IIBCE), Av. Italia 3318, Montevideo 11600, Uruguay.ORCID 0000-0002-9867-5094 Mariana PeraltaInstituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Av. Vélez Sarsfield 1611, Córdoba 5000, Argentina.
Maria Gabriela OrtegaInstituto Multidisciplinario de Biología Vegetal (IMBIV-CONICET), Av. Vélez Sarsfield 1611, Córdoba 5000, Argentina.ORCID 0000-0002-2400-9099 Juan A Abin-CarriquiryInstituto de Investigaciones Biológicas "Clemente Estable" (IIBCE), Av. Italia 3318, Montevideo 11600, Uruguay.
Loreto Martínez-GonzalezCentro de Investigaciones Biológicas Margarita Salas, CSIC, Calle Ramiro Maetzu 9, 28040 Madrid, Spain.ORCID 0000-0003-4593-4889 Juan Pablo GambiniCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.
Pablo DuarteCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.
Ana MartinezCentro de Investigaciones Biológicas Margarita Salas, CSIC, Calle Ramiro Maetzu 9, 28040 Madrid, Spain.ORCID 0000-0002-2707-8110 Ana ReyÁrea de Radioquímica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.ORCID 0000-0002-4560-9843 Javier GiglioCentro Uruguayo de Imagenología Molecular (CUDIM), Av. Ricaldoni 2010, Montevideo 11600, Uruguay.ORCID 0000-0002-2297-6739 Funding
Agencia Nacional de Investigación e Innovación POS_NAC_D_2020_1_164001 and POS_NAC_2018_1_151615
6 · The paper itselfAbstract
Natural products play a crucial role in drug discovery, primarily due to their structural complexity. The prenylated flavanone glabranin ((S)-5,7-dihydroxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one), isolated from the Dalea elegans plant species, has demonstrated neuroprotective effects, attributed to its inhibition of GSK-3β, as per our previous in silico studies. Given the enzyme's diverse functions and its potential as a target for neurodegenerative diseases, our group synthesized and evaluated an
Indexed as
FlavanonesGlycogen Synthase Kinase 3 betaAlzheimer DiseaseAnimalsBrainCarbon RadioisotopesHumansNeuroprotective AgentsPlant ExtractsCarbon RadioisotopesflavanoneFlavanonesGlycogen Synthase Kinase 3 betaNeuroprotective AgentsPlant ExtractsAlzheimer’s diseaseglabraninGSK-3β
Identifiers
PMID40005183
PMCPMC11857971
What OpenQuestion holds
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LicenceCC BY
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