Evidence map›Paper›PMID 40005144›Full record

ReviewMolecules (Basel, Switzerland)2025

Antiviral and Immune Enhancement Effect of

Pei Gao, Xinshan Li, Jianlei Ding, Bosen Peng, Muhammad Munir, Fei Liu, Limin Chao, Chengfei Li, Li Wang, Jinyou Ma and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pei GaoPostdoctoral Research Station, Henan Agriculture University, Zhengzhou 450002, China.ORCID 0009-0009-2935-8018
Xinshan LiCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Jianlei DingCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Bosen PengCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Muhammad MunirDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA14YW, UK.ORCID 0000-0003-4038-0370
Fei LiuCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Limin ChaoCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Chengfei LiPostdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang 453003, China.
Li WangPostdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang 453003, China.
Jinyou MaCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
Gaiping ZhangPostdoctoral Research Station, Henan Agriculture University, Zhengzhou 450002, China.

Funding

First-class Postdoctoral Research Grant in Henan Province 202001039Key Science and Technology Program of Henan Province 242102110004National Natural Science Foundation of China 32002285Program for Innovative Talents (in Science and Technology) in University of Henan Province 25HASTIT038
6 · The paper itself

Abstract

backgroundTraditional Chinese medicine offers potential therapeutic options for viral infections.

methodsResearch articles from 1990 to 2024 related to PG and viruses were obtained from databases, such as PubMed, Web of Science, and Science Direct, and systematically analysed.

resultsPG demonstrates inhibitory effects on viruses such as severe acute respiratory syndrome coronavirus and porcine reproductive and respiratory syndrome virus by blocking various stages of viral proliferation or activating the host immune system. It also reduces inflammation through NF-κB, PI3K/AKT, MAPK, and other signalling pathways, enhancing T cell and macrophage function and increasing host immunity. PG exhibits diverse pharmacological effects with promising clinical applications for antiviral and immune modulation. Given its medicinal significance, PG holds substantial potential for further exploration and development.

conclusionPG, due to its antiviral, anti-inflammatory, and immune-boosting properties, can be used as an antiviral drug.

Indexed as

Antiviral AgentsDrugs, Chinese HerbalPlant ExtractsPlatycodonVirus DiseasesAnimalsHumansSignal TransductionAntiviral AgentsDrugs, Chinese HerbalPlant Extractsantiviral activityimmunomodulationinflammation suppressionPlatycodon grandiflorusrespiratory infectionstraditional Chinese medicine

Identifiers

PMID40005144
PMCPMC11858313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.