Efficient Consecutive Synthesis of Fluorinated Isoflavone Analogs, X-Ray Structures, Hirshfeld Analysis, and Anticancer Activity Assessment.

Mohammed Salah Ayoup, Malak Daqa, Yousef Salama, Rand Hazzam, Mohammed B Hawsawi, Saied M Soliman, Nawaf Al-Maharik

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Flavonoids, Chalcones, and Their Fluorinated Derivatives-Recent Advances in Synthesis and Potential Medical Applications.Molecules (Basel, Switzerland) · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammed Salah AyoupDepartment of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.ORCID 0000-0001-6715-5478

Malak DaqaDepartment of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine.

Yousef SalamaAn-Najah Center for Cancer and Stem Cell Research, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine.ORCID 0000-0001-6254-6381

Rand HazzamDepartment of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine.

Mohammed B HawsawiDepartment of Chemistry, Faculty of Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0003-1527-5560

Saied M SolimanDepartment of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt.

Nawaf Al-MaharikDepartment of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus 00970, Palestine.ORCID 0000-0002-7014-6190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of 7-

Indexed as

Antineoplastic AgentsIsoflavonesCell ProliferationCrystallography, X-RayHalogenationHumansMCF-7 CellsModels, MolecularMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsIsoflavones4′-fluoroisflavones7-O-carboxmethyl-4′-fluoroisoflavoneanticancerMCF7 cancer cellsXRD crystallography

Identifiers

PMID40005107

DOI10.3390/molecules30040795

PMCPMC11857983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.