Influence of Neutralization Precipitation Conditions on the Physical Stability of Amorphous Solid Pharmaceuticals.

Zhihui Yuan, Xu Liao, Bowen Zhang, Asad Nawaz, Zunhua Li

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Effect of Solute Concentration and Filtration Rate on the Scale Production of a Physically Stable Amorphous Solid Form of Nilotinib.Pharmaceutics · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhihui YuanCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Xu LiaoCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Bowen ZhangSchool of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Asad NawazCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Zunhua LiCollege of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425199, China.

Funding

The Construct Program of Applied Characteristic Discipline in Hunan Province Nonethe Natural Science Foundation of Hunan Province 2023JJ50068the Scientific Research Project of Hunan University of Science and Engineering 23XKYZZ01

6 · The paper itself

Abstract

This research focused on the precipitation of amorphous forms of nilotinib with high physical stability through the manipulation of various parameters in the neutralization reaction, specifically the quantity of nilotinib, the pH value, and the concentration of HCl. To assess the physical stability of the amorphous nilotinib, various characterization techniques, including PXRD, DSC, and FBRM, were utilized in conjunction with analytical methods such as PDF, PCA, and R

Indexed as

accelerated stability testamorphous formneutralization precipitationphysical stability

Identifiers

PMID40005076

DOI10.3390/molecules30040764

PMCPMC11858484

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.