Evidence map›Paper›PMID 40005065›Full record

ArticleNutrients2025

Dietary Fatty Acid Composition Alters Gut Microbiome in Mice with Obesity-Induced Peripheral Neuropathy.

Mohamed H Noureldein, Amy E Rumora, Samuel J Teener, Diana M Rigan, John M Hayes, Faye E Mendelson, Andrew D Carter, Whitney G Rubin, Masha G Savelieff, Eva L Feldman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohamed H NoureldeinDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7021-1511
Amy E RumoraDepartment of Neurology, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-0788-3251
Samuel J TeenerDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0003-9072-8184
Diana M RiganDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4564-2130
John M HayesDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5677-2216
Faye E MendelsonDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-5601-7675
Andrew D CarterDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0006-7953-8998
Whitney G RubinDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Masha G SavelieffDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58202, USA.ORCID 0000-0001-5575-2494
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9162-2694

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler, Utpal Pajvani · 2003 to 2026
$36.7M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Schwann Cell Senescence and the Secretome Provide a Unifying Mechanism for the Onset and Progression of Diabetic NeuropathyR01DK130913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eva Lucille Feldman, Junguk Hur · 2022 to 2026
$3.3M
Sphingolipid and Fatty Acid Biology in Prediabetes and NeuropathyR00DK119366 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RUMORA, AMY E. · 2021 to 2023
$747k
Metabolic syndrome impairs oligodendrocyte metabolic support of neurons leading to Alzheimer’s disease/Alzheimer’s disease and related dementiasK99AG081390 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOURELDEIN, MOHAMED HUSSEIN MOHAMED · 2023 to 2024
$211k
Dr. John H. Doran Neuropathy Research Initiative not applicableMichigan Diabetes Research Center P30DK020572Nathan and Rose Milstein Research Fund not applicableNeuroNetwork for Emerging Therapies not applicableNIA NIH HHS K99 AG081390NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R00 DK119366NIDDK NIH HHS R01 DK130913NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255NIH HHS 1K99AG081390-00A1NIH HHS 1P30DK063608-00A20NIH HHS 1R00DK119366-00A1NIH HHS 1R01DK076169-00A1NIH HHS 1R01DK115255-00A1NIH HHS 1R01DK130913-00A1Richard and Jane Manoogian Foundation not applicableSinai Medical Staff Foundation not applicableTaubman Foundation not applicable
6 · The paper itself

Abstract

backgroundPeripheral neuropathy (PN), a complication of diabetes and obesity, progresses through a complex pathophysiology. Lifestyle interventions to manage systemic metabolism are recommended to prevent or slow PN, given the multifactorial risks of diabetes and obesity. A high-fat diet rich in saturated fatty acids (SFAs) induces PN, which a diet rich in monounsaturated fatty acids (MUFAs) rescues, independent of weight loss, suggesting factors beyond systemic metabolism impact nerve health. Interest has grown in gut microbiome mechanisms in PN, which is characterized by a distinct microbiota signature that correlates with sciatic nerve lipidome.

methodsHerein, we postulated that SFA- versus MUFA-rich diet would impact gut microbiome composition and correlate with PN development. To assess causality, we performed fecal microbiota transplantation (FMT) from donor mice fed SFA- versus MUFA-rich diet to lean recipient mice and assessed metabolic and PN phenotypes.

resultsWe found that the SFA-rich diet altered the microbiome community structure, which the MUFA-rich diet partially reversed. PN metrics correlated with several microbial families, some containing genera with feasible mechanisms of action for microbiome-mediated effects on PN. SFA and MUFA FMT did not impact metabolic phenotypes in recipient mice although SFA FMT marginally induced motor PN.

conclusionsThe involvement of diet-mediated changes in the microbiome on PN and gut-nerve axis may warrant further study.

Indexed as

Dietary FatsFatty AcidsGastrointestinal MicrobiomeObesityPeripheral Nervous System DiseasesAnimalsDiet, High-FatDisease Models, AnimalFatty Acids, MonounsaturatedFecal Microbiota TransplantationMaleMiceMice, Inbred C57BLDietary FatsFatty AcidsFatty Acids, Monounsaturatedfecal microbiota transplantationinflammationmonounsaturated fatty acidprediabetessaturated fatty acid

Identifiers

PMID40005065
PMCPMC11858455

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.