Evidence map›Paper›PMID 40005058›Full record

ArticleNutrients2025

Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice.

Samantha Varada, Stephen R Chamberlin, Lillie Bui, Mikah S Brandes, Noah Gladen-Kolarsky, Christopher J Harris, Wyatt Hack, Cody J Neff, Barbara H Brumbach, Amala Soumyanath and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Asiatic Acid AttenuatesInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Life (Basel, Switzerland) · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha VaradaDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.ORCID 0009-0000-0784-5442
Stephen R ChamberlinDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Lillie BuiDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Mikah S BrandesDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Noah Gladen-KolarskyDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Christopher J HarrisDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Wyatt HackDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Cody J NeffDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Barbara H BrumbachOHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR 97239, USA.
Amala SoumyanathDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.ORCID 0000-0003-1569-6453
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.ORCID 0000-0001-7305-2256
Nora E GrayDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Allison Lindauer · 2020 to 2026
$28.6M
Mechanisms underlying the cognitive effects of Centella asiatica water extract and constituent compounds in the 5xFAD mouse model of Alzheimer's DiseaseU19AT010829 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SOUMYANATH, AMALA · 2020 to 2024
$6.1M
Network models to capture multiple outcomes resulting from multi-component, salutogenic interventionsK08AT012477 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven Chamberlin · 2023 to 2026
$621k
BLRD VA I01 BX003440NCCIH NIH HHS K08 AT012477NCCIH NIH HHS U19 AT010829NIA NIH HHS P30 AG066518United States Department of Veterans Affairs O1BX003440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAntioxidantsCognitionMitochondriaPentacyclic TriterpenesAdministration, OralAmyloid beta-PeptidesAnimalsBrainCentellaDisease Models, AnimalFemaleMaleMemoryMiceMice, TransgenicAmyloid beta-PeptidesAntioxidantsasiatic acidPentacyclic Triterpenesantioxidantasiatic acidCentella asiaticamitochondrial functionNRF2

Identifiers

PMID40005058
PMCPMC11858387

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.