Evidence map›Paper›PMID 40005007›Full record

ArticleNutrients2025

Oxidative Balance Score Calculated Using Different Methods and Its Associations with Colorectal Cancer Risk.

Fangting Lin, Ruolin Zhou, Qingjian Ou, Kexin Tu, Yujing Fang, Caixia Zhang

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangting LinDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Ruolin ZhouDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Qingjian OuState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Kexin TuDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Yujing FangState Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Caixia ZhangDepartment of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0001-9671-9412

Funding

the National Natural Science Foundation of China 82473616
6 · The paper itself

Abstract

backgroundThe oxidative balance score (OBS) measures oxidative stress from diet and lifestyle, but research linking it to colorectal cancer (CRC) risk is scarce and varies in calculation methods.

methodsWe conducted a case-control study in Guangzhou, China, involving 2799 CRC cases and an equal number of sex- and age-matched controls. We adopted and compared four different methods for calculating the OBSs. The odds ratio (OR) and 95% confidence interval (95%CI) for the relationship between OBS and CRC risk were determined using an unconditional logistic regression model. Restricted cubic splines were used to explore potential non-linear relationships. Additionally, stratified analyses were performed by sex, and subgroup analyses were performed based on the tumor site.

resultsAmong the four OBSs assessed, OBS-1 demonstrated superior performance. Higher adherence to four OBSs was associated with a lower risk of CRC. The adjusted ORs (95%CIs) for the highest quartile compared to the lowest quartile were as follows: 0.42 (0.35, 0.50) for OBS-1, 0.43 (0.36, 0.51) for OBS-2, 0.50 (0.42, 0.59) for OBS-3, and 0.43 (0.36, 0.51) for OBS-4. Linear relationships were observed between four OBSs and CRC risk (all

conclusionsAll four OBSs were negatively associated with CRC risk, with OBS-1 showing the strongest association in our analysis.

Indexed as

Colorectal NeoplasmsOxidative StressAgedCase-Control StudiesChinaDietFemaleHumansLife StyleLogistic ModelsMaleMiddle AgedOdds RatioRisk Factorscase-control studycolorectal canceroxidative balance scoreoxidative stress

Identifiers

PMID40005007
PMCPMC11858281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.