Evidence map›Paper›PMID 40004969›Full record

ArticleNutrients2025

Endogenous Ketone Bodies Are Associated with Metabolic Vulnerability and Disability in Multiple Sclerosis.

Taylor R Wicks, Irina Shalaurova, Anna Wolska, Richard W Browne, Bianca Weinstock-Guttman, Robert Zivadinov, Alan T Remaley, James D Otvos, Murali Ramanathan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Frailty Exacerbates Disability in Progressive Multiple Sclerosis.Annals of clinical and translational neurology · 2026
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taylor R WicksDepartment of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.ORCID 0009-0004-5803-6222
Irina ShalaurovaLabCorp Diagnostics, Morrisville, NC 27560, USA.
Anna WolskaLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-9479-0741
Richard W BrowneBiotechnical and Clinical Laboratory Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
Bianca Weinstock-GuttmanDepartment of Neurology, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.ORCID 0000-0001-6732-151X
Robert ZivadinovBuffalo Neuroimaging Analysis Center, University at Buffalo, The State University of New York, Buffalo, NY 14203, USA.
Alan T RemaleyLabCorp Diagnostics, Morrisville, NC 27560, USA.
James D OtvosLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Murali RamanathanDepartment of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.

Funding

Department of Defense Multiple Sclerosis Research Program for the Office of the Congressionally Directed Medical Research Programs MS190096
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Ketone BodiesMultiple SclerosisMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingAdultBiomarkersCase-Control StudiesFemaleHumansInflammationMaleMiddle AgedOxidative StressBiomarkersKetone Bodiesacetoacetateantioxidant defensebeta-hydroxybutyrateketone bodieslipid peroxidationmetabolomicsmultiple sclerosis

Identifiers

PMID40004969
PMCPMC11858685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.