Evidence map›Paper›PMID 40004823›Full record

ReviewJournal of clinical medicine2025

Spinal Cord Infarction: Clinical and Neuroradiological Clues of a Rare Stroke Subtype.

Marialuisa Zedde, Arturo De Falco, Carla Zanferrari, Maria Guarino, Francesca Romana Pezzella, Shalom Haggiag, Gianni Cossu, Rocco Quatrale, Giuseppe Micieli, Massimo Del Sette and 1 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Thrombolysis in spinal cord infarction: Case report and systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Hypotension-Induced Transverse Spinal Cord Ischemia.European journal of case reports in internal medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marialuisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.ORCID 0000-0001-7530-818X
Arturo De FalcoNeurology and Stroke Unit, Ospedale del Mare, ASL Napoli 1 Centro, 80147 Naples, Italy.ORCID 0000-0002-5944-2984
Carla ZanferrariNeurology and Stroke Unit, ASST Melegnano-Martesana, 20070 Milan, Italy.
Maria GuarinoIRCCS Istituto Delle Scienze Neurologiche Di Bologna, 40139 Bologna, Italy.
Francesca Romana PezzellaStroke Unit, Dipartimento Di Neuroscienze, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy.
Shalom HaggiagNeurology Unit, Dipartimento Di Neuroscienze, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy.ORCID 0000-0002-5569-4121
Gianni CossuNeurology Unit, Department of Neuroscience, ARNAS Brotzu, 09047 Cagliari, Italy.
Rocco QuatraleDipartimento Di Scienze Neurologiche, UOC di Neurologia-Ospedale dell'Angelo-ULSS 3 Serenissima, 30174 Venezia-Mestre, Italy.
Giuseppe MicieliFormer Department of Emergency Neurology, IRCCS C. Mondino Foundation, 27100 Pavia, Italy.
Massimo Del SetteNeurology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Rosario PascarellaNeuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord infarction (SCI) of arterial origin is a rare vascular event, and its incidence is probably underestimated. There are no strong epidemiological data, and the diagnostic pathway is complex and sometimes incomplete. Furthermore, many cases may be misdiagnosed as other forms of acute and subacute myelopathies. The focus of this review is the clinical and neuroradiological issues in diagnosing SCI and their respective reliability in a clinical setting. The new proposed diagnostic criteria of SCI, although not covering all aspects, highlight the need for a comprehensive approach, including even atypical cases, as the lack of cord compression on Magnetic Resonance Imaging (MRI) is the only mandatory feature for diagnosis. Some MRI features are supportive of the diagnosis, particularly when the anterior spinal artery territory is involved and diffusion-weighted imaging (DWI) is used. Several etiologies can be considered, considering traditional vascular risk factors and diseases affecting the aorta and its main branches, yet a significant proportion of cases remain without a definite etiology. The strongest predictor of SCI diagnosis is a clinical variable, i.e., a time to nadir of severe deficits < 12 h.

Indexed as

aortadissectionDWIMRIowl’s eyesperiproceduralspinal cord infarctiontime

Identifiers

PMID40004823
PMCPMC11856212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.