Evidence map›Paper›PMID 40004537›Full record

ReviewGenes2025

Bidirectional Interplay Among Non-Coding RNAs, the Microbiome, and the Host During Development and Diseases.

Shanshan Nai, Jiaxian Song, Wenting Su, Xiaoqian Liu

Abstract readReview
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shanshan NaiState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Jiaxian SongState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Wenting SuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
Xiaoqian LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.

Funding

Shandong University 62450082463091
6 · The paper itself

Abstract

It is widely known that the dysregulation of non-coding RNAs (ncRNAs) and dysbiosis of the gut microbiome play significant roles in host development and the progression of various diseases. Emerging evidence has highlighted the bidirectional interplay between ncRNAs and the gut microbiome. This article aims to review the current understanding of the molecular mechanisms underlying the crosstalk between ncRNAs, especially microRNA (miRNA), and the gut microbiome in the context of development and diseases, such as colorectal cancer, inflammatory bowel diseases, neurological disorders, obesity, and cardiovascular disease. Ultimately, this review seeks to provide a foundation for exploring the potential roles of ncRNAs and gut microbiome interactions as biomarkers and therapeutic targets for clinical diagnosis and treatment, such as ncRNA mimics, antisense oligonucleotides, and small-molecule compounds, as well as probiotics, prebiotics, and diets.

Indexed as

Gastrointestinal MicrobiomeRNA, UntranslatedAnimalsCardiovascular DiseasesHumansInflammatory Bowel DiseasesMicroRNAsObesityMicroRNAsRNA, UntranslateddevelopmentdiseasesmicrobiomencRNAs

Identifiers

PMID40004537
PMCPMC11855195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.