Evidence map›Paper›PMID 40004500›Full record

ArticleGenes2025

The Relationship of the Pathogenic Variant rs721048 in the Intron of the

Marina Romanova, Saltanat Abdikerim, Kaisar Dauyey, Ziyo Gassanov, Nurlan Baltayev, Shyngys Satymbayev, Aigul Zhunussova, Dilyara Kaidarova, Gulnur Zhunussova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marina RomanovaLaboratory of Molecular Genetics, RSE "Institute of Genetics and Physiology" of the SC MSHE RK, Al-Farabi Ave., 93, Almaty 050060, Kazakhstan.ORCID 0000-0003-2557-8346
Saltanat AbdikerimLaboratory of Molecular Genetics, RSE "Institute of Genetics and Physiology" of the SC MSHE RK, Al-Farabi Ave., 93, Almaty 050060, Kazakhstan.
Kaisar DauyeyLaboratory of Molecular Genetics, RSE "Institute of Genetics and Physiology" of the SC MSHE RK, Al-Farabi Ave., 93, Almaty 050060, Kazakhstan.
Ziyo GassanovKazakh Institute of Oncology and Radiology, Almaty 050000, Kazakhstan.
Nurlan BaltayevAlmaty Oncology Centre, Almaty 050000, Kazakhstan.
Shyngys SatymbayevAlmaty Oncology Centre, Almaty 050000, Kazakhstan.
Aigul ZhunussovaLaboratory of Molecular Genetics, RSE "Institute of Genetics and Physiology" of the SC MSHE RK, Al-Farabi Ave., 93, Almaty 050060, Kazakhstan.
Dilyara KaidarovaKazakh Institute of Oncology and Radiology, Almaty 050000, Kazakhstan.ORCID 0000-0002-0969-5983
Gulnur ZhunussovaLaboratory of Molecular Genetics, RSE "Institute of Genetics and Physiology" of the SC MSHE RK, Al-Farabi Ave., 93, Almaty 050060, Kazakhstan.

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP19680315
6 · The paper itself

Abstract

backgroundProstate cancer (PC) is one of the most common oncological diseases among men. Up to 20% of PC cases are associated with hereditary risks or syndromes. The impact of common variants, particularly

methodsWe utilized the TruSight Cancer Sequencing Panel to assess pathological genomic variants in 72 male patients with histologically verified aggressive PC and 119 patients of Kazakh nationality with histologically confirmed CRC compared to the control group.

resultsA variant in the intron of the

conclusionsThe frequency of the

Indexed as

Colorectal NeoplasmsProstatic NeoplasmsAgedCase-Control StudiesGenetic Predisposition to DiseaseHumansIntronsKazakhstanMaleMiddle AgedPolymorphism, Single Nucleotidecolorectal cancerEHBP1next-generation sequencingpathogenic variantprostate cancerrs721048

Identifiers

PMID40004500
PMCPMC11855340

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.