Evidence map›Paper›PMID 40004493›Full record

ArticleGenes2025

The Association of Genetic Variants Within the Type XII Collagen and Tenascin C Genes with Knee Joint Laxity Measurements.

Samantha Beckley, Roopam Dey, Shaun Stinton, Willem van der Merwe, Thomas Branch, Alison V September, Michael Posthumus, Malcolm Collins

Abstract read
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In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha BeckleyHealth Through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.
Roopam DeyDivision of Biomedical Engineering and Division of Orthopaedic Surgery, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.ORCID 0000-0002-3616-1995
Shaun StintonEnd Range of Motion Improvement, Atlanta, GA 30324, USA.ORCID 0000-0002-2760-722X
Willem van der MerweHealth Through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.
Thomas BranchEnd Range of Motion Improvement, Atlanta, GA 30324, USA.
Alison V SeptemberHealth Through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.
Michael PosthumusHealth Through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.
Malcolm CollinsHealth Through Physical Activity, Lifestyle and Sport Research Centre (HPALS), Division of Physiological Sciences, Department of Human Biology, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.ORCID 0000-0002-2564-0480

Funding

South African Medical Research Council N/A
6 · The paper itself

Abstract

BACKGROUND/

objectivesTypes I, V, and XI collagen gene variants have been reported to associate with measurements of knee joint laxity and/or absolute knee ligament length changes. Type XII collagen and tenascin C are also ligament structural proteins whose expression is regulated by mechanical loading. This study investigated whether

methodsGenu recurvatum, anterior-posterior tibial translation, external-internal tibial rotation, and ligament length changes were measured in 128 healthy participants. They were genotyped for

resultsBoth the

conclusionsThese findings suggest that

Indexed as

Collagen Type XIIJoint InstabilityKnee JointPolymorphism, Single NucleotideTenascinAdultFemaleGenotypeHumansMaleMiddle AgedYoung AdultCOL12A1 protein, humanCollagen Type XIITenascinTNC protein, humananterior–posterior tibial translationexternal–internal tibial rotationgenu recurvatumknee laxityligamenttendon

Identifiers

PMID40004493
PMCPMC11855217

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.