Evidence map›Paper›PMID 40004452›Full record

ArticleGenes2025

Prevalence and Clinical Characteristics of

Karuna Maekawa, Shin-Ya Nishio, Kotaro Ishikawa, Masahiro Takahashi, Kozo Kumakawa, Mayuri Okami, Hidekane Yoshimura, Jun Nakayama, Masato Teraoka, Shin-Ichi Usami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karuna MaekawaDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Shin-Ya NishioDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0001-6640-2297
Kotaro IshikawaDepartment of Otolaryngology, National Rehabilitation Center for Persons with Disabilities, Tokorozawa 359-8555, Japan.
Masahiro TakahashiDepartment of Otorhinolaryngology, International University of Health and Welfare, Mita Hospital, Tokyo 108-8329, Japan.
Kozo KumakawaDepartment of Otorhinolaryngology, Akasaka Toranomon Clinic, Minato 107-0052, Japan.
Mayuri OkamiDepartment of Otorhinolaryngology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Hidekane YoshimuraDepartment of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0001-9601-7496
Jun NakayamaDepartment of Otorhinolaryngology, Shiga University of Medical Science, Otsu 520-2192, Japan.
Masato TeraokaDepartment of Otolaryngology, Head and Neck Surgery, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
Shin-Ichi UsamiDepartment of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-5068-6122

Funding

Japan Agency for Medical Research and Development JP16kk0205010, JP18ek0109363, JP21ek0109542, JP24ek0109741Ministry of Health, Labor and Welfare of Japan H29-Nanchitou(Nan)-Ippan-031, 20FC1048Wellcome Trust FC001048
6 · The paper itself

Abstract

BACKGROUND/

objectivesHearing loss is one of the most common sensorineural impairments, and approximately 60% of early-onset cases are due to genetic variations. The otogelin-like protein, encoded by the

methodsA total of 7056 Japanese patients with hearing loss were recruited, and based on massively parallel DNA sequencing on 158 target genes, we selected patients with biallelic

resultsTen affected individuals with

conclusionsDetermination of the phenotypes of genes causative of hearing loss is expected to greatly benefit patients with hearing loss as it can assist in predicting outcomes and lead to appropriate intervention, which, in

Indexed as

Hearing LossHearing Loss, SensorineuralMembrane ProteinsAdolescentAdultChildChild, PreschoolCohort StudiesEast Asian PeopleFemaleHumansJapanMaleMiddle AgedMutationPhenotypeMembrane ProteinsDFNB84Bmild-to-moderate hearing lossnon-syndromic hearing lossOTOGL

Identifiers

PMID40004452
PMCPMC11854685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.