ArticleGenes2025
Ecological Trait Differences Are Associated with Gene Expression in the Primary Visual Cortex of Primates.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primate species differ drastically from most other mammals in how they visually perceive their environments, which is particularly important for foraging, predator avoidance, and detection of social cues. BACKGROUND/
objectivesAlthough it is well established that primates display diversity in color vision and various ecological specializations, it is not understood how visual system characteristics and ecological adaptations may be associated with gene expression levels within the primary visual cortex (V1).
methodsWe performed RNA-Seq on V1 tissue samples from 28 individuals, representing 13 species of primates, including hominoids, cercopithecoids, and platyrrhines. We explored trait-dependent differential expression (DE) by contrasting species with differing visual system phenotypes and ecological traits.
resultsBetween 4-25% of genes were determined to be differentially expressed in primates that varied in type of color vision (trichromatic or polymorphic di/trichromatic), habitat use (arboreal or terrestrial), group size (large or small), and primary diet (frugivorous, folivorous, or omnivorous).
conclusionsInterestingly, our DE analyses revealed that humans and chimpanzees showed the most marked differences between any two species, even though they are only separated by 6-8 million years of independent evolution. These results show a combination of species-specific and trait-dependent differences in the evolution of gene expression in the primate visual cortex.
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