Evidence map›Paper›PMID 40004179›Full record

ArticleInternational journal of molecular sciences2025

Lower Sphingomyelin SM 42:1 Plasma Level in Coronary Artery Disease-Preliminary Study.

Tomasz Urbanowicz, Paweł Gutaj, Szymon Plewa, Ievgen Spasenenko, Beata Krasińska, Anna Olasińska-Wiśniewska, Dariusz Kowalczyk, Zbigniew Krasiński, Ewelina Grywalska, Mansur Rahnama-Hezavah and 4 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0001-8080-2764
Paweł GutajDepartment of Reproduction, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Szymon PlewaDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-812 Poznan, Poland.ORCID 0000-0002-9600-3980
Ievgen SpasenenkoDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0009-0009-6993-4606
Beata KrasińskaDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0002-3464-1645
Anna Olasińska-WiśniewskaCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland.ORCID 0000-0002-4213-8708
Dariusz KowalczykFaculty of Health Sciences, University of Kalisz, 62-800 Kalisz, Poland.ORCID 0000-0002-9512-8677
Zbigniew KrasińskiDepartment of Vascular, Endovascular Surgery, Angiology and Phlebology Medical, Poznan University of Medical Science, 61-848 Poznan, Poland.ORCID 0000-0002-2798-1959
Ewelina GrywalskaDepartment of Experimental Immunology, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-0451-4741
Mansur Rahnama-HezavahDepartment of Dental Surgery, Medical University of Lublin, 20-059 Lublin, Poland.
Mariusz KowalewskiThoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-067 Bydgoszcz, Poland.ORCID 0000-0002-5478-3245
Andrzej TykarskiDepartment of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, 61-848 Poznan, Poland.
Ewa Wender-OżegowskaDepartment of Reproduction, Poznan University of Medical Sciences, 60-535 Poznan, Poland.ORCID 0000-0002-5492-8651
Jan MatysiakDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-812 Poznan, Poland.ORCID 0000-0002-9993-1504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery atherosclerosis is a common condition characterized by different symptomatology and incidences of risk factors. The disease manifestation may differ; therefore, proper diagnosis is essential. The preventive, diagnostic, and therapeutic arms are still developing to improve patient outcomes. Among diagnostic steps, the non-invasive tools for evaluating non-classical factors related to metabolomic profiles are gaining attention. The aim of this study was to investigate possible metabolic profiling differences between patients with chronic coronary artery disease (CAD) and a control group based on plasma sphingomyelin levels. The study group consisted of 23 patients (72% male, median age of 69 (63-72) years) presenting with chronic coronary syndrome and confirmed epicardial disease in coronary angiography and 15 patients (33% male, median age of 70 (64-72) years) with normal angiographic results. Clinical data were recorded, and blood samples were collected for standard biochemical laboratory assessment and metabolomic profiling. The plasma sphingomyelin levels were evaluated in patients with different degrees of coronary artery atherosclerosis involvement. In addition, the severity of the epicardial disease was estimated by the Gensini Score. The study subgroups did not differ in terms of age (

Indexed as

Coronary Artery DiseaseSphingomyelinsAgedBiomarkersFemaleHumansMaleMiddle AgedBiomarkersSphingomyelinsCADGensinimetabolomicSM 42:1sphingomyelin

Identifiers

PMID40004179
PMCPMC11855572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.