Evidence map›Paper›PMID 40004178›Full record

ArticleInternational journal of molecular sciences2025

Bicyclic

Fanny Danton, Mohamed Othman, Ata Martin Lawson, Amaury Farce, Emmanuelle Lipka, Alina Ghinet, Ján Moncol, Abdelhabib Semlali, Adam Daïch

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fanny DantonNormandie Univ., UNILEHAVRE, CNRS, URCOM, 76600 Le Havre, France.
Mohamed OthmanNormandie Univ., UNILEHAVRE, CNRS, URCOM, 76600 Le Havre, France.ORCID 0000-0002-8379-5704
Ata Martin LawsonNormandie Univ., UNILEHAVRE, CNRS, URCOM, 76600 Le Havre, France.ORCID 0000-0002-1641-4190
Amaury FarceU995-LIRIC-Lille Inflammation Research International Center, CHU Lille, Inserm, Univ. Lille, 59000 Lille, France.ORCID 0000-0003-3992-9629
Emmanuelle LipkaFaculté des Sciences Pharmaceutiques et Biologiques de Lille, 3 Rue du Pr Laguesse, B.P. 83, 59006 Lille, France.
Alina GhinetUMR 1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Institut Pasteur de Lille, CHU Lille, Inserm, Univ. Lille, 59000 Lille, France.ORCID 0000-0001-6468-4331
Ján MoncolDepartment of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, SK-81237 Bratislava, Slovakia.ORCID 0000-0003-2153-9753
Abdelhabib SemlaliGroupe de Recherche en Écologie Buccale (GREB), Faculté de Médecine Dentaire, Université Laval, Québec, QC G1V 0A6, Canada.ORCID 0000-0002-5797-8304
Adam DaïchNormandie Univ., UNILEHAVRE, CNRS, URCOM, 76600 Le Havre, France.ORCID 0000-0002-6942-0519

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report in this contribution the synthesis and in vitro biological evaluation of a novel class of chiral thiazoloisoindolinone scaffolds as potent inhibitors against human farnesyltransferase (FTase-h). The targeted products, sulfides (

Indexed as

AmidesCysteineEnzyme InhibitorsFarnesyltranstransferaseHumansStructure-Activity RelationshipAmidesCysteineEnzyme InhibitorsFarnesyltranstransferaseamidation processbicyclic N,S-acetalfarnesyltransferase inhibitor (FTI)molecular modellingsulfoxidation and sulfonation reactions

Identifiers

PMID40004178
PMCPMC11855478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.