Evidence map›Paper›PMID 40004154›Full record

ArticleInternational journal of molecular sciences2025

Different Gut Microbiome Profiles in Patients with Transthyretin Amyloidosis with and Without Cardiac Involvement.

João Henrique Rissato, Natalia de Melo Pereira, Cristhian Espinoza Romero, Georgina Del Cisne Jadán Luzuriaga, Bruno Vaz Kerges Bueno, Caio Rebouças Fonseca Cafezeiro, Aristóteles Comte de Alencar Neto, Thaís Sousa Borges, Suenia Freitas Carvalhal, Félix Jose Alvarez Ramires and 3 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

João Henrique RissatoHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0002-6721-5474
Natalia de Melo PereiraHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Cristhian Espinoza RomeroHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Georgina Del Cisne Jadán LuzuriagaHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0002-6000-1297
Bruno Vaz Kerges BuenoHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Caio Rebouças Fonseca CafezeiroHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0001-5960-2952
Aristóteles Comte de Alencar NetoHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.ORCID 0000-0002-9524-0255
Thaís Sousa BorgesHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Suenia Freitas CarvalhalHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Félix Jose Alvarez RamiresHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Luciano NastariHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Charles MadyHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.
Fábio FernandesHeart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-220, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transthyretin amyloidosis (ATTR amyloidosis) is characterized by the buildup of amyloid protein in organs like the gut and the heart. As a result, hypoperfusion, edema, and dysautonomia cause an imbalance in the gut microbiome. We aimed to identify the gut microbiome composition in ATTR amyloidosis patients with and without heart involvement, as well in controls. Sixty participants were divided into three groups: 20 with ATTR amyloidosis and heart involvement (G1), 19 with ATTR amyloidosis but no heart disease (G2), and 21 controls (G3). The microbiome profiles were obtained through 16S rRNA gene sequencing. Additional evaluations included a clinical questionnaire, echocardiogram, six-minute walk tests, troponin, BNP, and genotype analysis. Compared to G3, G1, and G2 groups had different levels of

Indexed as

Amyloid Neuropathies, FamilialGastrointestinal MicrobiomeAgedCase-Control StudiesFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16Samyloidosiscardiomyopathiesgastrointestinal microbiomegastrointestinal tractheart failure

Identifiers

PMID40004154
PMCPMC11855458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.