Evidence map›Paper›PMID 40004139›Full record

ArticleInternational journal of molecular sciences2025

Proteomics and Expression of HIF2α/BNIP3L Signaling in Yak Brains at Different Altitudes.

Qian Zhang, Yan Cui, Sijiu Yu, Junfeng He, Yangyang Pan, Meng Wang, Jialing Che

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mechanisms Underlying Altitude-Induced and Group 3 Pulmonary Hypertension.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian ZhangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Yan CuiCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Sijiu YuGansu Province Livestock Embryo Engineering Research Center, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Junfeng HeCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.ORCID 0000-0001-7813-9481
Yangyang PanGansu Province Livestock Embryo Engineering Research Center, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Meng WangCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Jialing CheCollege of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.

Funding

he National Natural Science Foundation of China 32002241the Department of Education of Gansu Province: University Teachers Innovation Fund Project 2025B-097the Youth mentor support fund project of Gansu Agricultural University GAU-QDFC-2022-10
6 · The paper itself

Abstract

The yak, a unique inhabitant of low-oxygen environments, exhibits brain adaptability to hypoxic conditions. However, the impact of hypoxia on yak brain proteomics and the expression of the HIF2α/BNIP3L signaling pathway remains unexplored. This study utilized TMT-based proteomics analysis to identify differentially expressed proteins (DEPs) in the cerebral cortexes of 9-month-old yaks at high (

Indexed as

AltitudeBasic Helix-Loop-Helix ProteinsBrainMembrane ProteinsProteomicsSignal TransductionAnimalsAutophagyCattleCerebral CortexEndothelial PAS Domain-Containing Protein 1Basic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Membrane ProteinsBeclin1BNIP3Lbraincleaved caspase-3HIF2αLC3-IIyak

Identifiers

PMID40004139
PMCPMC11855096

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.