Evidence map›Paper›PMID 40004119›Full record

ArticleInternational journal of molecular sciences2025

Augmented Bone Morphogenetic Protein Signaling During TMJ Development Alters Morphology in a Timepoint-Dependent Manner.

Susannah C Midla, Maiko Omi-Sugihara, Madeline Cha, Coral Chen, Rafael Correia Cavalcante, Haichun Pan, Yuji Mishina, Hiroki Ueharu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susannah C MidlaDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.ORCID 0009-0004-6079-4962
Maiko Omi-SugiharaDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.ORCID 0000-0002-1347-9044
Madeline ChaDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
Coral ChenDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
Rafael Correia CavalcanteDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.ORCID 0000-0001-6466-5165
Haichun PanDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.
Yuji MishinaDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.ORCID 0000-0002-6268-4204
Hiroki UeharuDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA.ORCID 0000-0002-0648-9690

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
Molecular pathogenesis of craniosynostosis caused by enhanced BMP signalingR01DE020843 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2010 to 2019
$4.9M
A new model for spatio-temporal coupling of bone formation and bone resorption governed by osteoclastsR33AR078073 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI, PARK, DONGSU · 2023 to 2023
$393k
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
Japan Society for the Promotion of Science T22KJ22290NCRR NIH HHS S10 RR026475NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R33 AR078073NIDCR NIH HHS R01 DE020843NIDCR NIH HHS T32 DE007057NIH HHS 1R01DE020843-10S1NIH/NCRR S10RR026475-01NIH/NIAMS AR069620
6 · The paper itself

Abstract

The temporomandibular joint (TMJ) is unique in both developmental origin and functional maintenance. The role of bone morphogenic protein (BMP) signaling in endochondral ossification has been widely investigated but not in the context of the TMJ. We employed a histomorphometric analysis approach to understand how augmented BMP signaling in the cranial neural crest affects the postnatal development of the TMJ. Our analysis showed that cartilage length in the mandibular condyle was reduced in

Indexed as

Bone Morphogenetic ProteinsSignal TransductionTemporomandibular JointAnimalsChondrocytesMandibular CondyleMiceMice, TransgenicNeural CrestOsteogenesisBone Morphogenetic ProteinsBMPR1Acondylar cartilagecranial neural crest

Identifiers

PMID40004119
PMCPMC11855487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.