ArticleInternational journal of molecular sciences2025
Biofunctionalization of Collagen Barrier Membranes with Bone-Conditioned Medium, as a Natural Source of Growth Factors, Enhances Osteoblastic Cell Behavior.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Human Amniotic Epithelial Stem Cells and Osteoblast Cells Behavior on Collagen Membranes for Bone Guided Regeneration.International journal of molecular sciences · 2026Article
- The Effect of Defect Morphology and Membrane Fixation on 3D Graft Material Displacement During Primary Wound Closure in Horizontal Bone Augmentation-An Ex Vivo Study.Clinical oral implants research · 2026Article
- Collagen-Based Delivery Systems for the Prevention of Alveolitis: A Narrative Review and Rationale for Biopharmaceutical Development Requirements.Journal of functional biomaterials · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A key principle of guided bone regeneration (GBR) is the use of a barrier membrane to prevent cells from non-osteogenic tissues from interfering with bone regeneration in patients with hard tissue deficiencies. The aim of the study was to investigate whether the osteoinductive properties of bone-conditioned medium (BCM) obtained from cortical bone chips harvested at the surgical site can be transferred to a native bilayer collagen membrane (nbCM). BCM extracted within 20 or 40 min, which corresponds to a typical implant surgical procedure, and BCM extracted within 24 h, which corresponds to BCM released from the autologous bone chips in situ, contained significant and comparable amounts of TGF-β1, IGF-1, FGF-2, VEGF-A, and IL-11. Significant (
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Registered trials
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