Evidence map›Paper›PMID 40004065›Full record

ArticleInternational journal of molecular sciences2025

High-Throughput Screening of Five Compound Libraries for Anthelmintic Activity and Toxicity Leads to the Discovery of Two Flavonoid Compounds.

Giulio Galli, Marta Ruiz-Somacarrera, Laura González Del Palacio, Estela Melcón-Fernández, Rubén González-Pérez, Carlos García-Estrada, Maria Martinez-Valladares, Rafael Balaña-Fouce

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chalcone andMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giulio GalliDepartamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.ORCID 0000-0001-6854-5507
Marta Ruiz-SomacarreraDepartamento Sanidad Animal, Instituto de Ganadería de Montaña, CSIC-Universidad de León, Grulleros, 24346 León, Spain.ORCID 0000-0002-1620-2083
Laura González Del PalacioDepartamento Sanidad Animal, Instituto de Ganadería de Montaña, CSIC-Universidad de León, Grulleros, 24346 León, Spain.ORCID 0000-0002-6396-120X
Estela Melcón-FernándezDepartamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.ORCID 0000-0002-9663-060X
Rubén González-PérezDepartamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.
Carlos García-EstradaDepartamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.ORCID 0000-0001-5617-9669
Maria Martinez-ValladaresDepartamento Sanidad Animal, Instituto de Ganadería de Montaña, CSIC-Universidad de León, Grulleros, 24346 León, Spain.
Rafael Balaña-FouceDepartamento de Ciencias Biomédicas, Facultad de Veterinaria, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.ORCID 0000-0003-0418-6116

Funding

Agencia Estadal de Investigación PID2020-119035RB-100Agencia Estadal de Investigación PRE2021-096909Consejería de Educación de la Junta de Castilla y León EDU/1330/2023ESF Investing in your future EDU/1330/2023ESF Investing in your future PID2020-119035RB-100ESF Investing in your future PRE2021-096909Ministerio de Ciencia, Innovación y Universidades PID2020-119035RB-100Ministerio de Ciencia, Innovación y Universidades PRE2021-096909
6 · The paper itself

Abstract

Gastrointestinal nematode infections (GINs) in ruminants are a major constraint to efficient livestock production worldwide. Currently, only a limited number of anthelmintic drugs are available for the control of these infections, but their widespread use in preventive deworming campaigns and the incorrect administration of the drugs are responsible for the emergence of resistance. Therefore, new anthelmintic drugs are urgently needed. However, drug discovery methods for new anthelmintics based on GINs isolated from ruminants often have low throughput. In this study, a screening of five commercial collections of chemical compounds, including one collection of anti-infective drugs, three plant-based natural product collections, and one collection from the FDA-approved Chinese

Indexed as

AnthelminticsDrug DiscoveryFlavonoidsHigh-Throughput Screening AssaysSmall Molecule LibrariesAnimalsHaemonchusHumansMiceAnthelminticsFlavonoidsSmall Molecule Librariesanthelminticchalcone derivativeshigh-throughput screeningoctenidineorganoidselective indextolfenpyradtoxicity

Identifiers

PMID40004065
PMCPMC11855827

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.