Evidence map›Paper›PMID 40004063›Full record

ArticleInternational journal of molecular sciences2025

Effect of Vitamin E on Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

David Segura Cobos, Esperanza Enedina Díaz Salgado, Dante Amato, Sinaí Ernesto Cardoso García, Tomás Ernesto Villamar Duque, Anayantzin Paulina Heredia Antúnez, Leonardo Del Valle Mondragón, Gil Alfonso Magos Guerrero, Elizabeth Alejandrina Guzmán Hernández

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David Segura CobosFaculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.ORCID 0000-0002-7460-1920
Esperanza Enedina Díaz SalgadoFaculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.
Dante AmatoFaculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.
Sinaí Ernesto Cardoso GarcíaBioterium, Universidad Panamericana, Mexico City 03920, Mexico.ORCID 0009-0002-7151-5303
Tomás Ernesto Villamar DuqueGeneral Bioterium, Faculty of Superior Studies Iztacala, Biology, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.ORCID 0000-0002-6094-7314
Anayantzin Paulina Heredia AntúnezGeneral Bioterium, Faculty of Superior Studies Iztacala, Biology, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.ORCID 0009-0003-2188-7309
Leonardo Del Valle MondragónDepartment of Pharmacology, National Institute of Cardiology Ignacio Chavez, Mexico City 04510, Mexico.ORCID 0000-0002-2999-1050
Gil Alfonso Magos GuerreroDepartment of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City 04510, Mexico.
Elizabeth Alejandrina Guzmán HernándezFaculty of Higher Studies Iztacala, National Autonomous University of Mexico (UNAM), Tlalnepantla 54090, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus; oxidative stress plays a key role in the pathogenesis of DN. The objective of this study was to evaluate the antioxidant effect of vitamin E on diabetic nephropathy. A control group and three groups of rats with streptozotocin-induced diabetes mellitus (untreated diabetic rats and diabetic rats treated with vitamin E 250 and 500 mg/kg) were studied. After 4 weeks of treatment, the kidneys were removed under anesthesia with sodium pentobarbital. The kidneys were weighed, the AT

Indexed as

AntioxidantsDiabetes Mellitus, ExperimentalDiabetic NephropathiesVitamin EAnimalsCatalaseGlutathione PeroxidaseKidneyKidney CortexMaleOxidative StressRatsRats, WistarReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2StreptozocinAntioxidantsCatalaseGlutathione PeroxidaseReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2StreptozocinSuperoxide DismutaseVitamin EantioxidantAT1 receptordiabetic nephropathyvitamin E

Identifiers

PMID40004063
PMCPMC11855467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.