Evidence map›Paper›PMID 40004042›Full record

ArticleInternational journal of molecular sciences2025

SARS-CoV-2-ORF-3a Mediates Apoptosis Through Mitochondrial Dysfunction Modulated by the K

Muhammad Suhaib Qudus, Uzair Afaq, Siyu Liu, Kailang Wu, Chen Yu, Mingfu Tian, Jianguo Wu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. The Impact of Aging Oral Health on Long COVID-19.Journal of dental research · 2025
    Review
  5. Special Issue "Viral Infections and Host Immune Responses".International journal of molecular sciences · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muhammad Suhaib QudusState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.ORCID 0000-0002-7236-0502
Uzair AfaqState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Siyu LiuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.ORCID 0000-0002-9455-202X
Kailang WuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Chen YuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Mingfu TianState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Jianguo WuState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.ORCID 0000-0002-8326-2895

Funding

National Key R&D Program of China 2021YFF0702004
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) causes pulmonary edema, which disrupts the lung alveoli-capillary barrier and leads to pulmonary cell apoptosis, the main cause of death. However, the molecular mechanism behind

Indexed as

ApoptosisCOVID-19MitochondriaPotassium ChannelsSARS-CoV-2Viroporin ProteinsAnimalsChlorocebus aethiopsHumansPotassiumVero Cellsmitochondrial K(ATP) channelORF3a protein, SARS-CoV-2PotassiumPotassium ChannelsViroporin ProteinsapoptosisMitochondrial ATP-sensitive Potassium Channel (MitoKATP)mitochondrial dysfunctionORF-3aSARS-CoV-2

Identifiers

PMID40004042
PMCPMC11855091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.