Evidence map›Paper›PMID 40004031›Full record

ArticleInternational journal of molecular sciences2025

The Involvement of RIPK1 in Alopecia Areata.

Hyunju Kim, Mei Zheng, Seungchan An, In Guk Park, Leegu Song, Minsoo Noh, Jong-Hyuk Sung

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyunju KimEpi Biotech Co., Ltd., Incheon 21983, Republic of Korea.
Mei ZhengEpi Biotech Co., Ltd., Incheon 21983, Republic of Korea.ORCID 0000-0002-8694-455X
Seungchan AnNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-5840-8987
In Guk ParkNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Leegu SongEpi Biotech Co., Ltd., Incheon 21983, Republic of Korea.
Minsoo NohNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0002-4020-5372
Jong-Hyuk SungEpi Biotech Co., Ltd., Incheon 21983, Republic of Korea.

Funding

Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea RS-2024-00351858
6 · The paper itself

Abstract

We have previously demonstrated that receptor-interacting serine threonine kinase 1 (RIPK1) is expressed in hair follicles and regulates the hair cycle. In a mouse model, RIPK1 inhibitors also accelerated the telogen-to-anagen transition and elongated the anagen period. Here, we first investigated the involvement of RIPK1 in alopecia areata (AA). The mRNA and protein expression of RIPK1 was increased in the skin of an AA mouse model. Single-cell RNA sequencing and immunohistochemistry showed that RIPK1 was highly increased in dendritic cells (DCs) and CD8

Indexed as

Alopecia AreataReceptor-Interacting Protein Serine-Threonine KinasesAnimalsCD8-Positive T-LymphocytesDendritic CellsDisease Models, AnimalHair FollicleImidazolesIndolesMiceMice, Inbred C57BLImidazolesIndolesnecrostatin-1Receptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mousealopecia areataCD8+ T celldendritic cellGSK2982772Necrostatin-1sRIPK1

Identifiers

PMID40004031
PMCPMC11855397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.