Enhancing Niacinamide Skin Penetration via Other Skin Brightening Agents: A Molecular Dynamics Simulation Study.

Kamolrat Somboon, Choon-Peng Chng, Changjin Huang, Shikhar Gupta

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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Kamolrat SomboonBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore.

Choon-Peng ChngSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.ORCID 0000-0002-3707-8747

Changjin HuangSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore.ORCID 0000-0002-1941-1200

Shikhar GuptaP&G Singapore Innovation Center (SgIC), 70 Biopolis Street, Singapore 138547, Singapore.ORCID 0000-0003-0500-1080

Funding

A*STAR BMRC Strategic Positioning Fund (SPF)-A*STAR-P&G Collaboration Grant H23HW10006

6 · The paper itself

Abstract

Niacinamide, a derivative of vitamin B3, has been shown to reduce skin pigmentation (i.e., acting as a brightening agent) and inflammatory responses such as dermatitis and acne vulgaris. However, niacinamide is a hydrophilic compound and poor partitioning to the lipid matrix in the uppermost layer of the skin (the stratum corneum or SC) limits its delivery to the skin. This necessitates the use of penetration enhancers to increase its bio-availability. In this study, we used computer simulations to investigate the skin penetration of niacinamide alone and in combination with other brightening agents that are also shown to be skin penetration enhancers, namely undecylenoyl phenylalanine (Sepiwhite

Indexed as

Molecular Dynamics SimulationNiacinamideSkinSkin AbsorptionSkin Lightening PreparationsSkin PigmentationAdministration, CutaneousHumansLipid BilayersLipid BilayersNiacinamideSkin Lightening Preparationsbisabololniacinamideskin brighteningskin penetrationsucrose dilaurateundecylenoyl phenylalanine

Identifiers

PMID40004021

DOI10.3390/ijms26041555

PMCPMC11855608

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.